Blastic NK-Cell Lymphoma

Blastic NK cell lymphoma (a.k.a. CD4+CD56+ hematodermic neoplasm) is an extremely rare, aggressive form of lymphoma that affects the natural killer cells of the immune system. Natural killer cells are beneficial specialized lymphocytes that attack viruses and tumor cells. Unlike extranodal NK/T cell lymphoma, blastic NK cell lymphoma is not associated with the Epstein-Barr virus. This type of lymphoma affects mostly elderly patients, and only a few cases are documented each year. The first case was documented in 1994.

Diagnosis

Blastic NK cell lymphoma resembles leukemia as well as other cutaneous lymhomas and skin diseases and can only be diagnosed in the lab where natural killer cells are analyzed for specific markers. The CD56 antigen is present in Blastic NK cell Lymphoma, which is a known surface marker for natural killer cells.

Treatment

Blastic NK cell lymphoma is resistant to chemotherapy and radiotherapy. Aggressive chemotherapy associated with radiotherapy followed by bone marrow transplantation still produces poor outcomes.

Cancer Support Groups

SupportGroups.com builds awareness and support for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma. If you are a friend or parent of a person that has been diagnosed with Lymphoma, or you have been diagnosed with Lymphoma, you are not alone. Share personal experiences, evaluate information and get support during times of need, illness, treatment or recovery.

Dive Deeper

Non-Hodgkin's Lymphoma Information Pages:

Childhood Lymphoma Information Pages:

More Articles

More Articles

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is a relatively rare B-cell subtype of non-Hodgkin'...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

Lymphomatous meningitis [LM], also known as leukemic meningitis, is an extremely serious peripheral cancer that attacks the tissue that covers the...

Since so many chemotherapy agents can affect a patient’s sex drive and fertility, thinking about these issues prior...

Secondary cancers are cancers that develop as a result of chemotherapy and/or...

One of the greatest fears of lymphoma survivors is that they’ll relapse and have to undergo treatment again. This fear is normal but awful to...

Over the years, various classification systems have been used to differentiate lymphoma types including the Rappaport Classification (used until...

If you are new to this website or are looking for guidance to a specific page, here is a list of links to articles that can help you. The "Main...

Often the one who makes the first diagnosis of Hodgkin's Lymphoma / Disease is the person affected. There are some...

Lymphedema is abnormal swelling due to the presence of excess lymphatic fluid within the tissues. This swelling occurs when the...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

Advances in the treatment of Hodgkin's lymphoma have resulted in remarkable survival rates, even for...