Nodal Marginal Zone Lymphoma

Nodal Marginal Zone Lymphoma (NMZL) is an indolent B-cell lymphoma that is found mostly in the lymph nodes. The disease is rare and only accounts for 1% of all Non-Hodgkin’s Lymphomas (NHL). It is most commonly diagnosed in older patients, with women more susceptible than men.

The disease is classified as a marginal zone lymphoma because the mutation occurs in the marginal zone of the B-cells. Due to its confinement in the lymph nodes, this disease is also classified as nodal.

Diagnosis and Staging

Symtoms include:

  • Painless swelling of the lymph nodes
  • Fever
  • Night sweats
  • Fatigue
  • Weight loss

Diagnosis is made using a lymph node biopsy. Other tests, such as X-rays, CT scan, PET scan, ultrasound, and bone marrow biopsy are used to stage the disease. Staging is as follows:

Stage I
Only one group of lymph nodes is involved,
Stage II
Two groups of lymph nodes are involved, but they are on the same side of the diaphragm.
Stage III
Lymph nodes on both sides of the diaphragm are involved. The spleen is considered a lymph node in this staging system, so its involvement marks stage III.
Stage IV
The bone marrow, liver, or other organs are involved.

Most patients are diagnosed in the earlier stages of disease.

Treatment

As this is a very slow growing disease, the "Watch and Wait" method may be employed for patients who don’t have many symptoms. Other treatment include:

Chemotherapy
NMZL is very reactive to chemotherapy. Administration of the drugs chlorambucil and/or fludarabine usually results in remission of the disease.
Radiation
Radiotherapy is given alone in the early stages of disease, or in combination with chemotherapy for late stages of the disease.
Radiolabeled Isotopes
Radioimmunotherapy treatments such as the Zevalin regimen are being researched as a treatment for marginal zone lymphomas and shows promising results.
Clinical Trials
Patients who are looking for more advanced treatment or who have lymphoma that does not respond to standard treatment may want to consider a clinical study. Click here to find clinical trials in your area.

Related Articles

More Articles

More Articles

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is a relatively rare B-cell subtype of non-Hodgkin'...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

Lymphomatous meningitis [LM], also known as leukemic meningitis, is an extremely serious peripheral cancer that attacks the tissue that covers the...

Since so many chemotherapy agents can affect a patient’s sex drive and fertility, thinking about these issues prior...

Secondary cancers are cancers that develop as a result of chemotherapy and/or...

One of the greatest fears of lymphoma survivors is that they’ll relapse and have to undergo treatment again. This fear is normal but awful to...

Over the years, various classification systems have been used to differentiate lymphoma types including the Rappaport Classification (used until...

If you are new to this website or are looking for guidance to a specific page, here is a list of links to articles that can help you. The "Main...

Often the one who makes the first diagnosis of Hodgkin's Lymphoma / Disease is the person affected. There are some...

Lymphedema is abnormal swelling due to the presence of excess lymphatic fluid within the tissues. This swelling occurs when the...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

Advances in the treatment of Hodgkin's lymphoma have resulted in remarkable survival rates, even for...