WHO Lymphoma Classification: System of Lymphoma Types

Over the years, various classification systems have been used to differentiate lymphoma types including the Rappaport Classification (used until the 70's), the Working Formulation, the National Cancer Institute Working Formulation, and the Revised European-American Lymphoma Classification (REAL).

We have chosen to present the World Health Organization's International Classification of Diseases (WHO ICD).

The WHO classification has its origins in the 1850s. The first edition, known as the International List of Causes of Death, was adopted by the International Statistical Institute in 1893. The ICD is the international standard diagnostic classification. It is used to classify diseases and other health problems recorded on many types of health and vital records including death certificates and health records. These records also provide the basis for the compilation of national mortality and morbidity statistics by WHO Member States.

The older Rappaport, Working Formulation, and REAL categories are described in a separate section for reference. This might be helpful if a patient's records state some of the classifications of older lymphoma types.

Hodgkin's Disease Classification

  • Lymphocytic-histiocytic predominance
  • Nodular sclerosis
  • Mixed cellularity
  • Lymphocytic depletion
  • Other Hodgkin's disease
  • Hodgkin's disease, unspecified

Follicular Lymphoma Classification

  • Small cleaved cell, follicular
  • Mixed small cleaved and large cell, follicular
  • Large cell, follicular
  • Other follicular non-Hodgkin's lymphoma types
  • Follicular non-Hodgkin's lymphoma, unspecified
    • Nodular non-Hodgkin's lymphoma NOS

Diffuse Non-Hodgkin's Lymphoma Classification

Peripheral and cutaneous T-cell lymphomas

  • Mycosis fungoides
  • Sézary's disease
  • T-zone lymphoma
  • Lymphoepithelioid lymphoma
    • Lennert's lymphoma
  • Peripheral T-cell lymphoma
  • Other and unspecified T-cell lymphomas

Other and unspecified types of non-Hodgkin's lymphoma

  • Lymphosarcoma
  • B-cell Lymphoma Classification, unspecified
  • Other specified types of non-Hodgkin's lymphoma
    • Malignant:
      • reticuloendotheliosis
      • reticulosis
    • Microglioma
  • Non-Hodgkin's lymphoma, unspecified type
    • Lymphoma NOS
    • Malignant lymphoma NOS
    • Non-Hodgkin's lymphoma NOS

Malignant immunoproliferative diseases

  • Waldenström's macroglobulinaemia
  • Alpha heavy chain disease
  • Gamma heavy chain disease
    • Franklin's disease
  • Immunoproliferative small intestinal disease
    • Mediterranean disease
  • Other malignant immunoproliferative diseases
  • Malignant immunoproliferative disease, unspecified
    • Immunoproliferative disease NOS

Multiple myeloma and malignant plasma cell neoplasms

  • Multiple myeloma
    • Kahler's disease
    • Myelomatosis
    • Excludes: solitary myeloma
  • Plasma cell leukemia
  • Plasmacytoma, extramedullary
    • Malignant plasma cell tumour NOS
    • Plasmacytoma NOS
    • Solitary myeloma

Lymphoid leukemia

Myeloid leukemia

  • Includes:
    • granulocytic
    • myelogenous
  • Acute myeloid leukemia
    • Excludes: acute exacerbation of chronic myeloid leukemia
  • Chronic myeloid leukemia
  • Subacute myeloid leukemia
  • Myeloid sarcoma
    • Chloroma
    • Granulocytic sarcoma
  • Acute promyelocytic leukemia
  • Acute myelomonocytic leukemia
  • Other myeloid leukemia
  • Myeloid leukemia, unspecified

Monocytic leukemia

  • Includes: monocytoid leukemia
  • Acute monocytic leukemia
    • Excludes: acute exacerbation of chronic monocytic leukemia
  • Chronic monocytic leukemia
  • Subacute monocytic leukemia
  • Other monocytic leukemia
  • Monocytic leukemia , unspecified

Other leukemias of specified cell type

  • Acute erythraemia and erythroleukemia
    • Acute erythraemic myelosis
    • Di Guglielmo's disease
  • Chronic erythraemia
    • Heilmeyer-Schöner disease
  • Acute megakaryoblastic leukemia
    • leukemia :
      • megakaryoblastic (acute)
      • megakaryocytic (acute)
  • Mast cell leukemia
  • Acute panmyelosis
  • Acute myelofibrosis
  • Other specified leukemia s
    • Lymphosarcoma cell leukemia

Leukemia of unspecified cell type

  • Acute leukemia of unspecified cell type
    • Blast cell leukemia
    • Stem cell leukemia
  • Chronic leukemia of unspecified cell type
  • Subacute leukemia of unspecified cell type
  • Other leukemia of unspecified cell type
  • leukemia , unspecified

Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue

  • Letterer-Siwe disease
    • Nonlipid:
      • reticuloendotheliosis
      • reticulosis
  • Malignant histiocytosis
    • Histiocytic medullary reticulosis
  • Malignant mast cell tumour
    • Malignant:
      • mastocytoma
      • mastocytosis
    • Mast cell sarcoma
      • Excludes: mast cell leukemia
      • mastocytosis (cutaneous)
  • True histiocytic lymphoma
  • Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue
  • Malignant neoplasm of lymphoid, haematopoietic and related tissue, unspecified

Related Articles

Lymphomas by Location

Non-Hodgkin's Lymphoma Information Pages:

Photo: Pexels

More Articles

More Articles

The term NK T cell lymphoma refers to one of two subtypes of lymphoma that affect the NK (Natural Killer)...

Canine lymphoma is a fairly common cancer in American dogs. The most commonly seen lymphoma in America is a type called Lymphosarcoma, although...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

Marginal zone lymphomas (MZL) are indolent lymphomas that affect the B-cells. The...

Large Cell Lymphoma (LCL) is typically an aggressive (fast growing) cancer of either the B cell or T cell type. They are one of the most common...

A B cell is a type of lymphocyte that produces antibodies to fight infections. These are the most prevalent lymphocytes in the bloodstream and are...

Aggressive Non-Hodgkin’s Lymphomas (NHLs) are fast growing cancers (as opposed to indolent cancers). They involve...

A lymphoma prognosis varies greatly depending on the type of lymphoma. There are more than 35 types of lymphoma, including 5 types of...

What causes lymphoma is not well known. DNA mutations may be what causes lymphoma to develop but what triggers these mutations is...

Often the one who makes the first diagnosis of Hodgkin's Lymphoma / Disease is the person affected. There are some...

Lymphedema is abnormal swelling due to the presence of excess lymphatic fluid within the tissues. This swelling occurs when the...

RICE is an acronym for an anti-cancer treatment that expresses a combination chemotherapeutic regimen. This regimen is written variously as "R+ICE...

Hodgkin's Disease—also referred to as Hodgkin's Lymphoma, these are the exact same diseases, just...

Lymphoma is a cancer affecting the white blood cells (lymphocytes) of the body's immune system. The cells begin to grow abnormally and much faster...

Canine lymphoma, just like lymphoma in humans, can be separated into stages,...