The Classifications and Stages of Lymphoma Diagnosis: What To Look For Early On

A lymphoma diagnosis is not difficult to determine once a patient and doctor begin to look for signs of cancer. However, lymphoma–especially non-Hodgkin lymphoma–can be something of a silent killer. Symptoms are frequently minor or nonexistent in the early stages. Furthermore, lymphoma symptoms mimic symptoms of common sickness that are familiar and not necessarily threatening to most patients.


Non-Hodgkin's lymphoma symptoms are not specific to the disease. For this reason, it is very important that you tell your doctor during regular checkups about any symptoms that you might be experiencing. They include:

Unexplained weight loss
Sudden and unexpected weight loss of 10% or more of total body weight could be a cause for concern.

Swollen lymph nodes
Lymphoma may cause swelling of lymph nodes in the neck, chest, abdomen and on the skin. Lymph nodes in the neck frequently swell in cases of a sinus infection or can be symptomatic of the flu. But if they persist for a long time or occur apart from other sicknesses they might be cause for concern. Lymph node swelling in the armpits or abdomen might be cause for more immediate concern. Lymphoma may also cause swelling in the chest area which may interfere with breathing. Lymphomas of the skin often appear as itchy red or purple lumps. Swollen lymph nodes are usually tender and painful to some degree. However, in the case of non-Hodgkin lymphoma, lymph nodes might swell and become firm without any evident pain.

Recurring Fevers
Obviously, fever can be a sign of just about anything. When fever recurs for no apparent reason, especially in conjunction with other symptoms, it could be a sign of lymphoma.

Night sweats
These will usually occur in conjunction with a fever.

Fatigue / Lack of energy
Again, this can be related to many things but in combination with other symptoms might be significant.

Itchy skin (pruritis) and rashes can be a sign of lymphoma.

Lymphoma Diagnosis

Once a physician has determined that symptoms are not related to minor infections or other causes, tests will be performed to determine if a patient has lymphoma. Diagnostic tests for lymphoma may include one or more of the following:

Blood tests
Blood test results cannot confirm lymphoma but they can signal that something is wrong. A high lymphocyte count or a high lactate dehydrogenase (LDH) count might be cause for further investigation. More on the myriad blood count tests can be found here.

X-rays, CT scanning, MRI's, PET scans, etc, may be used to look inside of the body to look for unusual growths.

A biopsy is the only way to truly confirm or deny the presence of lymphoma. Because a biopsy involves taking a tissue sample from a lymph node or other infected area and is, therefore, a surgical procedure, it is usually preceded by other tests such as those mentioned above. Pathologists examine the biopsy in several different ways to determine not only the presence of lymphoma but to also determine if it is malignant and to identify the type of lymphoma.

Bone marrow sample
Non-Hodgkin lymphoma frequently spreads to the bone marrow and therefore a bone marrow biopsy is a common diagnostic procedure.

Classification and Staging

Following a positive diagnosis, the medical team will classify and stage the lymphoma. Staging is outlined below. For more on lymphoma classification (determining the type of lymphoma) please see this page


Once non-Hodgkin's lymphoma is identified, more tests must be done to find out if the cancer has spread throughout the body. This testing is called "staging". Your doctor needs to know the stage of your disease to devise an appropriate treatment plan. Lymphoma staging may involve one or more of the following steps:

Clinical review
Prior test results will be reviewed in light of a diagnosis to help to determine staging.

Additional blood work. Blood tests may be done to determine kidney and liver function.

Lumbar Puncture
This is also known as a "spinal tap," which involves the withdrawal and examination of spinal fluid. This is usually done in cases where a physician believes that the disease might have spread to the nervous system.

Chest x-rays and CT scans are common methods for observing the extent to which lymphoma has spread.

This procedure, which involves examining vital organs through a surgical hole in the abdomen, is largely obsolete, having been replaced by non-invasive methods such as CT scanning.


The "Ann Arbor System" is the most widely used system for describing stages of non-Hodgkin's lymphoma (except in the case of Cutaneous T-Cell Lymphoma - Mycosis Fungoids - Sezary Syndrome which has a separate staging system).

Stage I: If either of the following is present it means the disease is stage I
The lymphoma is in a lymph node or nodes in only 1 region, such as the neck, groin, underarm, and so on. The cancer is found only in 1 area of a single organ outside of the lymph system (IE).

Stage II: If either of the following is present it means the disease is stage II:
The lymphoma is in 2 or more groups of lymph nodes on the same side of (above or below) the diaphragm (the muscle that aids breathing and separates the chest and abdomen). For example, this might include nodes in the underarm and neck area but not the combination of underarm and groin nodes. The lymphoma extends locally from a single group of lymph node(s) into a nearby organ (IIE). It may also affect other groups of lymph nodes on the same side of the diaphragm.

Stage III: If either of the following is present it means the disease is stage III:

The lymphoma is found in lymph node areas on both sides of (above and below) the diaphragm. The cancer may also have extended into an area or organ next to the lymph nodes (IIIE), into the spleen (IIIS), or both (IIIE,S).

Stage IV: If either of the following is present it means the disease is stage IV:
The lymphoma has spread outside of the lymph system into an organ that is not right next to an involved node. The lymphoma has spread to the bone marrow, liver, brain or spinal cord, or the pleura (thin lining of the lungs).

Each Stage Is Also Assigned An A or B

The letter A is added if the person doesn't have any symptoms of lymphoma.

The letter B is added (stage IIIB, for example) if any of the following symptoms are present:

  • Unexplained weight loss (more than 10% of weight)
  • Soaking night sweats
  • Unexplained fever > 100°

Related Reading

Sources: The American Cancer Society, American Society of Hematology, MedlinePlus
Photo: Pexels

More Articles

More Articles is pleased to have the Lymphoma Information Network in the family of associates. We've agreed to ship items...

The question ought to be what are myelodysplastic syndromes (MDS), since this is a group of similar blood and bone marrow diseases that...

Merkel Cell Carcinoma (MCC) is a very rare and aggressive skin cancer that usually develops when a person is in his or her 70s. It is...

Radiation Therapy Topics


At some point, the Seattle biotech company Cell Therapeutics Inc (CTI) should earn an entry in the Guinness Book of World Records for utter and...

Site Beginnings

This site was started as Lymphoma Resource Page(s) in 1994. The site was designed to collect lymphoma...

Three papers appearing in the journal Blood and pointing towards a regulator-suppressor pill could offer hope to blood cancer...

The US Food and Drug Administration (FDA) has granted a third so-called Breakthrough Therapy Designation for the investigational oral...

The US Food and Drug Administration today has approved an expanded use of Imbruvica (ibrutinib) in patients with...

The U.S. Food and Drug Administration has announced that it has granted "Breakthrough Therapy Designation" for the investigational agent...

According to a new study published in the Proceedings of the National Academy of Sciences, a team from the University of California, San...

Pharmacyclics has announced that the company has submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) for...

New research suggests that frontline radioimmunotherapy...

Gilead Sciences has announced results of the company's Phase II study of its investigational compound idelalisib, an oral inhibitor of...