Anaplastic Large Cell (Ki-1 / CD-30) Lymphoma

Anaplastic large cell lymphoma (ALCL) is a rare form of indolent (slow growing) Non-Hodgkin’s Lymphoma (NHL) that affects T-cells. It accounts for 1 in 50 cases of NHL and is more common in children and men. This cancer often affects the lymph nodes, skin, liver, lungs, and bone marrow.

This disease can be systematic (occurring throughout the body) or cutaneous (occurring in or on the skin).

Diagnosis and Staging

ALCL presents with typical lymphoma symptoms, including swollen, painless lymph nodes, night sweats, fever, weight loss, and fatigue.

Diagnosis is made via lymph node biopsy. Other test, such as CT scans, PET scans, ultrasounds, and chest X-rays are used for staging. The stages are as follows:

Stage I
Cancerous cells are found in only one lymph node group or one area outside of the lymphatic system
Stage II
Two lymph groups are affected on the same side of the diaphragm, or one lymph group and a nearby organ are affected.
Stage III
Lymph groups on both sides of the diaphragm are involved. Lymph cells may also have moved to one internal organ, such as the liver or lungs. Cells may also have metastasized to the spleen.
Stage IV
More than one organ is involved. Bone marrow may also be affected.

Treatment

Treatments vary depending on the stage of the disease and may include one or more of the following:

  • Chemotherapy, especially the CHOP regimen
  • Radiation is given for the earlier stages of disease, or in combination with chemotherapy for later stages of the disease.
  • Stem cell transplant/bone marrow transplant is used in very advanced cases.

Related Articles

More Articles

More Articles

According to a study by Japanese researchers, the SMILE combination chemotherapy protocol is effective against extranodal natural killer/T-cell...

Patients treated with maintenance rituximab had three times longer progression-free survival. This is a summary of an article published in the...

When you consider that the adult human body has anywhere from 300 to 700 lymph nodes, the better question might not be where ARE they located, but...

This entry looks at a non-Hodgkin's lymphoma called true histiocytic lymphoma (THL), also referred to as diffuse histiocytic lymphoma, and...

Lymphomatous meningitis [LM], also known as leukemic meningitis, is an extremely serious peripheral cancer that attacks the tissue that covers the...

Hodgkin's Disease—also referred to as Hodgkin's Lymphoma, these are the exact same diseases, just...

Intravascular lymphoma is a subtype of 'Lymphoma', an umbrella term that loosely refers to several dozen...

While the average lifespan for hamsters is only about 2.5 years, and they are therefore less prone to long-term illnesses, it is possible for a...

Burkitt's lymphoma is an aggressive B-cell lymphoma that is common in children...

Lymphoma is a cancer of the lymphatic system, causing B-cell or...

The term NK T cell lymphoma refers to one of two subtypes of lymphoma that affect the NK (Natural Killer)...

Lymphoma is a life-threatening disease, but is very treatable in most cases. The 5-year survival for patients diagnosed with non-Hodgkin's...

T cell lymphoma treatment options for these cancers are not especially effective and there is no absolute consensus about optimal treatments for...

Marginal zone lymphomas (MZL) are indolent lymphomas that affect the B-cells. The...

Lymphomas can arise from most any lymphatic tissue (lymph nodes, spleen, thymus, mucosa associated lymphoid...