Chemotherapy - Vincristine

Brand Names: Oncovin, VCR, Vincasar Pfs

Vincristine is a chemotherapy drug that is administered for the treatment of acute leukemia, neuroblastoma, thyroid cancer, and lymphoma. It functions as an alkylating agent, meaning it prevents the replication of tumor cells by damaging the DNA.

The drug is used in the treatment of both Hodgkin and Non-Hodgkin's Lymphoma, and is administered in conjunction with other chemotherapy drugs in the following regimens:

  • Stanford-V (adriamycin, mustargen, bleomycin, vinblastine, oncoving, etoposide, prednisone)
  • BEACOPP (bleomycin, etoposide, adriamycin, cytoxan, oncovin, prednisone, procarbazine)
  • CHOP (cytoxan, adriamycin, oncovin, prednisone)
  • CHOP-R (CHOP + rituxan)
  • MOPP (mustargen, oncovin, procarbazine, prednisone)

Drug Administration

Vincristine is given intravenously (IV). It is a vesicant, meaning it will irritate arteries, so it should be given through a vein only.

Side Effects

The most common side effect of vincristine use is hair loss. Less common side effects include low blood counts, constipation, nausea, abdominal pain, mouth sores, unusual bleeding and/or bruising, bone pain, and blood in the stool or urine.

Other Treatment Options

  • The Zevalin radioimmunotherapy regimen is now approved for certain types of NHL.

For more information on Hodgkin's disease, please see the following pages:

For more information on Non-Hodgkin Lymphoma, please see the following pages:

chemotherapy

More Articles

More Articles

In T cell lymphoma, T lymphocytes, which are an essential part of the body's immune response, become malignant. T cell lymphomas account for about...

Lymphomatoid Papulosis (LyP) is a rare skin disorder that involves cancerous looking skin lesions. It is more than a skin condition; it is the...

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is a relatively rare B-cell subtype of non-Hodgkin'...

T-Cell Lymphoblastic Lymphoma (T-LBL) is a very rare subtype of non-Hodgkin's lymphoma. It tends to develop in...

In general, a diagnosis of T-cell lymphoma denotes a poorer prognosis than a diagnosis of B-cell lymphoma. One of...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

The term NK T cell lymphoma refers to one of two subtypes of lymphoma that affect the NK (Natural Killer)...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...