Chemotherapy - Vincristine

Brand Names: Oncovin, VCR, Vincasar Pfs

Vincristine is a chemotherapy drug that is administered for the treatment of acute leukemia, neuroblastoma, thyroid cancer, and lymphoma. It functions as an alkylating agent, meaning it prevents the replication of tumor cells by damaging the DNA.

The drug is used in the treatment of both Hodgkin and Non-Hodgkin's Lymphoma, and is administered in conjunction with other chemotherapy drugs in the following regimens:

  • Stanford-V (adriamycin, mustargen, bleomycin, vinblastine, oncoving, etoposide, prednisone)
  • BEACOPP (bleomycin, etoposide, adriamycin, cytoxan, oncovin, prednisone, procarbazine)
  • CHOP (cytoxan, adriamycin, oncovin, prednisone)
  • CHOP-R (CHOP + rituxan)
  • MOPP (mustargen, oncovin, procarbazine, prednisone)

Drug Administration

Vincristine is given intravenously (IV). It is a vesicant, meaning it will irritate arteries, so it should be given through a vein only.

Side Effects

The most common side effect of vincristine use is hair loss. Less common side effects include low blood counts, constipation, nausea, abdominal pain, mouth sores, unusual bleeding and/or bruising, bone pain, and blood in the stool or urine.

Other Treatment Options

  • The Zevalin radioimmunotherapy regimen is now approved for certain types of NHL.

For more information on Hodgkin's disease, please see the following pages:

For more information on Non-Hodgkin Lymphoma, please see the following pages:

More Articles

More Articles

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

Hodgkin's Disease—also referred to as Hodgkin's Lymphoma, these are the exact same diseases, just...

The Follicular Lymphoma International Prognostic Index, or FLIPI, is a standardized guide to help oncological diagnosticians accurately calculate...

Diffuse large B cell lymphoma prognosis is contingent upon several factors, and can be determined by using a well-...

The term 'metastatic lymphoma' does not refer to a diagnosis. Unlike many of the subtypes of lymphoma we have...

Diagnosing lymphoma is one of the more difficult diagnoses to make in cancer medicine, and contrary to perception, diagnosing lymphoma is not made...

Burkitt's lymphoma is an aggressive B-cell lymphoma that is common in children...

Treatment for Non-Hodgkin’s Lymphomas (NHL) differs from patient to patient. The regimen used depends on the type of...

Large Cell Lymphoma (LCL) is typically an aggressive (fast growing) cancer of either the B cell or T cell type. They are one of the most common...

Follicular lymphoma is classified as a Non-Hodgkin's Lymphoma. It is an indolent (slow-growing) cancer that affects...

Aggressive Non-Hodgkin’s Lymphomas (NHLs) are fast growing cancers (as opposed to indolent cancers). They involve...

Lymphoma is not difficult to diagnose once a patient and doctor begin to look for signs of cancer. However, Lymphoma–especially...

A lymphoma prognosis varies greatly depending on the type of lymphoma. There are more than 35 types of lymphoma, including 5 types of...

The lymphatic system, or lymph system, defends the body from foreign invasion by disease causing agents such as viruses, bacteria, or fungi. The...

Lymphoma is a cancer of the lymphatic system, causing B-cell or...