Testicular Lymphoma: Symptoms, Diagnosis, Prognosis, and Treatment

This entry looks at testicular lymphoma, or non-Hodgkin's lymphoma of the testis. 'Lymphoma' is an umbrella term that loosely refers to several dozen independent categorical types and subtypes of cancers of the lymphatic system; testicular lymphoma is one of those subtypes.

The disease is called primary testicular lymphoma (PTL) if it is found to originate in the testis. It is (less commonly) called secondary testicular lymphoma if the disease originates elsewhere in the body and has spread to the testis. This entry will chiefly address PTL.

What is Testicular Lymphoma?

Testicular lymphoma is a rare extranodal subtype of non-Hodgkin's lymphoma affecting the male testicles and is often pathologically diagnosed as an extranodal diffuse large B-cell lymphoma (DLBCL) of the testis. It is a rare cancer of the testis, amounting to less than ten percent of such cancers. The disease tends to have an aggressive clinical course, It is most often diagnosed in elderly men; however, an exception is in younger, male HIV positive patients, in whom PTL has a comparatively high incidence.

Symptoms and Diagnosis of Testicular Lymphoma

Most commonly, testicular lymphoma presents as a painless unilateral (one-sided) mass on the testis, although in about one-fifth of the cases, it is bilateral (affecting both testis). Self-testicular exams properly carried out can contribute to early detection.

Diagnosing testicular lymphoma will almost invariably require an orchidectomy (also spelled orchiectomy), which is the surgical removal of a testis (a procedure which keeps the scrotum and penis otherwise intact).

Prognosis and Treatment of Testicular Lymphoma

Treatment of testicular lymphoma generally involves some form of doxorubicin-based, systemic combination chemotherapy, such as R-CHOP. Another treatment is involved-field radiotherapy to the testis. In some cases, patients may receive both chemotherapy and radiation. The earlier the stage of the disease, the higher the success rate of treatment, although in the case of testicular lymphoma it appears that there is even a success rate difference between early stage disease (stage I and stage II).

When testicular lymphoma recurs following treatment, common sites include the central nervous system (CNS). For this reason, CNS prophylaxis (preventive medicine) could be necessary, in which case patients might receive intrathecal chemotherapy involving methotrexate, cytarabine and dexametasone.

Prognosis for most patients with testicular lymphoma is good, especially those diagnosed and treated for early-stage disease. However, later-stage disease is more difficult to treat and prognosis in these cases is considered rather poor.

Sources

Photo: Pexels

More Articles

More Articles

This article looks at the Non-Hodgkin's Lymphoma survival rate as well as the Non-Hodgkin's Lymphoma mortality rate ....

The term NK T cell lymphoma refers to one of two subtypes of lymphoma that affect the NK (Natural Killer)...

Canine lymphoma is a fairly common cancer in American dogs. The most commonly seen lymphoma in America is a type called Lymphosarcoma, although...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

Marginal zone lymphomas (MZL) are indolent lymphomas that affect the B-cells. The...

Large Cell Lymphoma (LCL) is typically an aggressive (fast growing) cancer of either the B cell or T cell type. They are one of the most common...

A B cell is a type of lymphocyte that produces antibodies to fight infections. These are the most prevalent lymphocytes in the bloodstream and are...

Aggressive Non-Hodgkin’s Lymphomas (NHLs) are fast growing cancers (as opposed to indolent cancers). They involve...

A lymphoma prognosis varies greatly depending on the type of lymphoma. There are more than 35 types of lymphoma, including 5 types of...

What causes lymphoma is not well known. DNA mutations may be what causes lymphoma to develop but what triggers these mutations is...

Often the one who makes the first diagnosis of Hodgkin's Lymphoma / Disease is the person affected. There are some...

Lymphedema is abnormal swelling due to the presence of excess lymphatic fluid within the tissues. This swelling occurs when the...

RICE is an acronym for an anti-cancer treatment that expresses a combination chemotherapeutic regimen. This regimen is written variously as "R+ICE...

Hodgkin's Disease—also referred to as Hodgkin's Lymphoma, these are the exact same diseases, just...

Lymphoma is a cancer affecting the white blood cells (lymphocytes) of the body's immune system. The cells begin to grow abnormally and much faster...