Cutaneous Malt Lymphoma

Cutaneous MALT lymphoma is a cancer of the lymphatic system, targeting b-cell lymphocytes. MALT lymphomas attack mucosa-associated lymphoid tissue, and cutaneous MALT lymphoma specifically targets the skin, especially the second layer of skin. It is a non-Hodgkin's lymphoma and is sometimes referred to as extranodal marginal zone B cell lymphoma.

Call

Demographics

MALT lymphomas are relatively rare, comprising only eight percent of all b-cell lymphomas. The cutaneous sub-type is even rarer. There is no evidence to suggest a higher prevalence among any particular ethnic or cultural group.

Symptoms

Cutaneous MALT lymphoma is characterized by a nodule under the skin, a bright red rash, or a lump on the skin with a mushroom-like appearance. These are present most often in the extremities. It affects men and women equally, and there seems to be a relationship between MALT lymphomas in general and persons with autoimmune disorders, especially Sjorgren's syndrome or Hashimoto's thyroiditis.

Diagnosis

A doctor will typically attempt to diagnose cutaneous MALT lymphoma with a biopsy of the skin lesions. There is also research linking the disease to the presence of the H. pylori bacteria and, in the particular case of the cutaneous type, B. burgdorferi, so the oncologist may also test for those, although the link with the former is less pronounced in the cutaneous type of lymphoma.

The vast majority of MALT lymphomas are diagnosed as stage IE, meaning the cancer was discovered early in stage one and carries a very low rate of mortality

Treatment

Because cutaneous MALT lymphoma tends to be highly localized, it can typically be treated with radiation therapy or with surgery. Cutaneous MALT lymphoma is somewhat unique among MALT lymphomas in that it is more responsive to antibiotic treatments with may remove underlying bacterial causes. Chemotherapy is an option is the disease has spread beyond its origin, or if it has proven refractory on antibiotics.

Prognosis

Because cutaneous MALT lymphoma is slowing growing and tends to remain highly localized, prognosis is generally positive. Assuming the disease has not become systemic, radiation and surgery may both be curative. Local reoccurrence does happen, but it is extremely rare for this form of cancer to spread beyond its point of origin. For these reasons, the rate of survival at five years is 97 percent. Some sources place the disease free ten year survival rate at 77 percent.

Call

More Articles

More Articles

This entry looks at Non Hodgkin's Lymphoma in the lungs, clinically known as pulmonary lymphoma, one of the subtypes of lymphoma. 'Lymphoma' is an...

In order to prevent developing any subtype of lymphoma, it would be helpful to know the causes of lymphoma. Unfortunately, in virtually every case...

BEAM chemotherapy is an acronym representing a small family of combination chemotherapy regimens that are used chiefly as salvage regimens in the...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

The Erythrocyte Sedimentation Rate (ESR - sometimes called sed rate or sedimentation rate) is a nonspecific screening test for various...

Blood counts can be used to identify disease and monitor patient health during cancer treatments. Though these tests cannot diagnose lymphoma on...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

According to a study by Japanese researchers, the SMILE combination chemotherapy protocol is effective against extranodal natural killer/T-cell...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Patients treated with maintenance rituximab had three times longer progression-free survival. This is a summary of an article published in the...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...

Since so many chemotherapy agents can affect a patient’s sex drive and fertility, thinking about these issues prior...