![]() |
| Site Navigation | Older Lymphoma Classification and Typing Schemes |
|
The group of cancers under the
general term Lymphoma is quite broad. The distinctions between types of lymphoma are based
on the different characteristics of the cancerous cells. Over the years, different
classification systems have been used to differentiate lymphomas:
|
|||
| Historically, uniform treatment of patients with lymphoma has been hampered by the lack of uniformity in these classification systems. | |||
|
The following comparison of the Working formulation and the Rappaport system is shown in case older records use some of this terminology:
|
|||
Working formulation Rappaport classification
Low-grade
A.small lymphocytic, consistent with diffuse lymphocytic, well
chronic lymphocytic leukemia (SL) -differentiated (DLWD)
B.follicular, predominantly small nodular lymphocytic poorly
cleaved cell (FSC) differentiated (NLPD)
C.follicular, mixed small cleaved nodular mixed, lymphocytic
and large cell (FM) and histiocytic (NM)
Intermediate-grade
D. follicular, predominantly large nodular histiocytic(NH)
cell (FL)
E. diffuse, small cleaved cell diffuse lymphocytic poorly
(DSC) differentiated (DLDP)
F. diffuse mixed, small and large diffuse mixed, lymphocytic
cell (DM) and histiocytic (DM)
G. diffuse, large cell cleaved or diffuse histiocytic (DH)
noncleaved cell (DL)
High-grade
H. immunoblastic, large cell (IBL) diffuse histiocytic (DH)
I. lymphoblastic, convoluted or diffuse lymphoblastic (DL)
nonconvoluted cell (LL)
J. small noncleaved cell, Burkitt's diffuse undifferentiated,
or non-Burkitt's (SNC) Burkitt's or non-Burkitt's (DU)
As the understanding of lymphoma has improved and as the
histopathologic The REAL Classification B-cell neoplasms I. Precursor B-cell neoplasm: precursor B-lymphoblastic leukemia/lymphoma II. Peripheral B-cell neoplasms A. B-cell chronic lymphocytic leukemia/prolymphocytic leukemia/small lymphocytic lymphoma B. Lymphoplasmacytoid lymphoma/immunocytoma C. Mantle cell lymphoma D. Follicle center cell lymphoma, follicular 1. Provisional cytologic grades: I small cell, II mixed small and large cell, III large cell 2. Provisional subtype: diffuse, predominantly small cell type E. Marginal zone B-cell lymphoma 1. Extranodal (MALT-type +/- monocytoid B cells) 2. Provisional subtype: nodal (+/- monocytoid B cells) F. Provisional entity: splenic marginal zone lymphoma (+/- villous lymphocytes) G. Hairy cell leukemia H. Plasmacytoma/plasma cell myeloma I. Diffuse large B-cell lymphoma 1. Subtype: primary mediastinal (thymic) B-cell lymphoma J. Burkitt's lymphoma K. Provisional entity: high-grade B-cell lymphoma, Burkitt-like T-cell and putative NK-cell neoplasms I. Precursor T-cell neoplasm: precursor T-lymphoblastic lymphoma/leukemia II. Peripheral T-cell and NK-cell neoplasms A. T-cell chronic lymphocytic leukemia / prolymphocytic leukemia B. Large granular lymphocyte leukemia 1. T-cell type 2. NK-cell type C. Mycosis fungoides/Sezary's syndrome D. Peripheral T-cell lymphomas, unspecified 1. Provisional cytologic categories: medium-sized cell, mixed medium and large cell, large cell, lymphoepithelioid cell 2. Provisional subtype: hepatosplenic gamma/delta T-cell lymphoma 3. Provisional subtype: subcutaneous panniculitic T-cell lymphoma E. Angioimmunoblastic T-cell lymphoma F. Angiocentric lymphoma G. Intestinal T-cell lymphoma (+/- enteropathy associated) H. Adult T-cell lymphoma/leukemia I. Anaplastic large cell lymphoma 1. CD30+ -cell type 2. T-cell type 3. Null-cell types J. Provisional entity: anaplastic large cell lymphoma, Hodgkin's-like Hodgkin's Disease (now known to be a B-cell neoplasm) I. Lymphocyte predominance II. Nodular sclerosis III. Mixed cellularity IV. Lymphocyte depletion V. Provisional entity: lymphocyte-rich classical Hodgkin's disease Back to Lymphomas - Current Classifications For more information on Adult Non-Hodgkin's lymphoma, please see the
For more information on Childhood Non-Hodgkin's Lymphoma:
For more information on Hodgkin's Disease: The home page - gateway to support and more: This page is a work in progress - if
you have more complete information, references, or other Copyright © 1998-2005 Lymphoma
Information Network - All Rights Reserved |