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Childhood Non-Hodgkin's Lymphoma

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The terms "non-Hodgkin's lymphoma" and "non-Hodgkin lymphoma" are used interchangeably on this site as are the terms "Hodgkin's disease," "Hodgkin lymphoma," and "Hodgkin's lymphoma."

The third most common childhood cancer is lymphoma; it accounts for 10% of all childhood cancer diagnoses. Of these diagnoses, about 60% are Non-Hodgkin’s Lymphomas. Children are vulnerable to the same types of lymphoma as adults. Although diagnosis of lymphoma in a child is especially traumatic for everyone involved, it must be remembered that younger patients generally have higher recovery rates than adults. This page briefly outlines non-Hodgkin's lymphoma; please use the numerous hyperlinks for more in depth information.

Non-Hodgkin’s Lymphoma (NHL) is a cancerous growth of B-cells or T-cells in the lymphatic system. There are four main types that occur in children:

[More on childhood NHL statistics from ACS]

Symptoms and Diagnosis

Lymphomas present a wide range of symptoms, all of which can indicate less severe conditions. However, if you or your child exhibits several of these symptoms, an appointment with a doctor would be wise.

  • Swelling of the lymph nodes in the neck, underarm, or groin. Swelling is usually painless.
  • Fever
  • Weight loss
  • Fatigue
  • Night sweats
  • Shortness of breath

A diagnosis is made after several tests are conducted, including:

  • Physical examination
  • Chest X-ray
  • Biopsy of a Lymph Node
  • Bone Marrow Biopsy
  • CT Scan
  • Blood Tests
  • Ultrasound

Staging

The general staging rules for NHL are:

Stage I
Involvement of one lymph node group or one area outside the lymph nodes
Stage II
There are two groups of lymph nodes involved on the same side of the diaphragm, or there is one lymph group and one non-lymphatic organ involved. Alternatively, if the lymphoma started in the stomach it is considered Stage II.
Stage III
Tumors occur in lymph groups on both sides of the diaphragm, or began in the chest or abdomen. Also, if the tumors occur around the spine, it is considered Stage III.
Stage IV
This stage is categorized by the involvement of the bone marrow or brain.

Treatments

Typical NHL treatments include

  • Chemotherapy
  • Radiation
  • Stem Cell Transplant
  • Clinical Trials
  • Monoclonal antibodies, such as Rituxan

Late Effects

After treatment, a child's health may still be affected by health problems that show up after cancer treatment (sometimes years later). These are known as a "late effects." For this reason, your child's health must be closely monitored throughout the remainder of their lives. For more information, see the American Cancer Society's Childhood Cancer: Late Effects of Cancer Treatment.

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SupportGroups.com aims to build awareness and provide support for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma. If you are a friend or parent of a person that has been diagnosed with Lymphoma, or you have been diagnosed with Lymphoma, you are not alone. Share personal experiences, evaluate information and get support during times of need, illness, treatment or recovery.

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The information provided on the Lymphoma Information Network is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational and educational purposes. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Neither the owners or employees of LymphomaInfo.net nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. Please see our Legal Statement for further information.

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Zevalin® (Ibritumomab tiuxetan) is a form of radioimmunotherapy (a radiolabeled monoclonal antibody) for treatment of patients with relapsed or refractory, low‑grade or follicular B‑cell non‑Hodgkin's lymphoma (NHL). "Refractory" refers to a disease that does not respond to treatment.

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SupportGroups.com aims to build awareness and provide support for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma. If you are a friend or parent of a person that has been diagnosed with Lymphoma, or you have been diagnosed with Lymphoma, you are not alone. Share personal experiences, evaluate information and get support during times of need, illness, treatment or recovery.

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Since the early 1970s, incidence rates for non-Hodgkin’s lymphoma have nearly doubled. Incidence rates for Hodgkin’s disease have declined about 60%. Better means of diagnosis has also increased the number as doctors better understand cancer of lymphocytes verses other diseases.
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