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Lymphoblastic Lymphoma
Lymphoblastic Lymphoma is an aggressive cancer that can affect either type of lymphocyte. It is most commonly found in T-cells (almost 90% of cases), but some Lymphoblastic Lymphomas arise from immature B-cells. Though this cancer is rare and accounts for only 2% of Non-Hodgkin’s diagnoses per year, it is very common in children. In fact, up to 30% of all childhood lymphomas diagnosed per year will be Lymphoblastic Lymphomas.
In most cases, this disease progresses to Stage IV prior to diagnosis. Tumors in this stage have spread to the bone marrow, spleen, and central nervous system. Symptoms include swollen lymph nodes, fatigue, weight loss, and night sweats.
Diagnosis and Staging
To accurately diagnose and stage this disease, doctors may use blood work and bone marrow or lymph node biopsies. By examining the biopsied tissue under a microscope, doctors can identify the mutations that cause this type of lymphoma and make an accurate diagnosis. To determine the spread and stage of the disease, doctors may also use chest X-rays, CT scans, PET scans, or ultrasounds. Staging is as follows:
- Stage I
- Involvement of one group of lymph nodes on one side of the diaphragm.
- Stage II
- Involvement of two groups of lymph nodes on the same side of the diaphragm.
- Stage III
- Lymph involvement on both sides of the diaphragm. This stage may also be marked by involvement of the lungs or a mass in the chest.
- Stage IV
- Marked by spread into the central nervous system and/or bone marrow.
Treatment

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Join the online Non-Hodgkin's and Hodgkin's Lymphoma Support Groups for free and talk to others who are facing the same challenges you are.
The most common treatment for the disease is chemotherapy. The CHOP regimen has been used with great success, as has a newer regimen called hyper-CVAD (cytoxan, vincristine, adriamycin, and dexamethasone).
In some cases, radiation therapy will be used with chemotherapy, though it is never used as a sole treatment.
Radioimmunotherapy is also being researched as a treatment for lymphoblastic lymphoma.
Cancer Patients have more options through clinical studies. Follow this link to learn more and find a clinical study opportunity near you.
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Non-Hodgkin's Lymphoma Information Pages:
- The Zevalin radioimmunotherapy regimen is now approved for certain types of NHL.
- Non-Hodgkin's Lymphomas
- Non-Hodgkin's Lymphoma: Diagnosis
- Non-Hodgkin's Lymphoma: Aggressive Lymphomas
- Non-Hodgkin's Lymphoma: Indolent Lymphomas
- Non-Hodgkin's Lymphoma: Treatment
- Non-Hodgkin's Lymphoma: Resources
- Bone Marrow and Stem Cell Transplants
- Childhood Lymphoma
- Childhood Non-Hodgkin's Lymphoma
- Childhood Non-Hodgkin's Lymphoma: Diagnosis
- Childhood Non-Hodgkin's Lymphoma: Types and Staging
- Childhood Non-Hodgkin's Lymphoma: Treatment
- Childhood Lymphoma: Resources

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For nearly 30 years, Cancer Treatment Centers of America has been dedicated to finding the right combination of personalized cancer treatments for their patients. Call (877) 399-6937 or click here to learn more about treatment options.
Support Groups
For individuals, friends and families who are looking to connect during life's challenging times. Share personal experiences, evaluate information and get support during times of need, illness, treatment or recovery.
Find a Treatment Facility Near You
Click on a state below to find Lymphoma treatment options that could be right for you.
Select a State Below
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The information provided on the Lymphoma Information Network is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational and educational purposes. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Neither the owners or employees of LymphomaInfo.net nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. Please see our Legal Statement for further information.
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