Green tea extract shows clinical efficacy against chronic lymphocytic leukemia (CLL)

ABSTRACT

In this ASCO 2010 abstract, researchers examined whether the green tea extract epigallocatechin 3 gallate (EGCG) has 'clinical efficacy' for chronic lymphocytic leukemia (CLL) patients.

COHORT

42 eligible patients received EGCG 2000 mg twice daily for up to 6 months.

RESULTS

Overall, 67% (28 patients) had a clinical response; either
A) A decline in ALC (absolute lymphocyte count) of 20% or greater, or
B) A 50% reduction in the 'sum of the products of all nodal areas at some point during the 6 months of active treatment.

Side effects included:
- Transaminitis (31% grade 1, 12% grade 2)
- Abdominal pain (21% grade 1, 7% grade 2, 2% grade 3)
- Nausea (55% grade 1, 2% grade 2).

CONCLUSIONS

"Daily oral EGCG in the Polyphenon E preparation was well tolerated by CLL patients in this phase II trial. Declines in ALC and/or lymphadenopathy were observed in the majority of patients. EGCG containing green tea extracts may have potential as disease stabilizing agents in patients with early-stage CLL."

PUBLICATIONS

These results are presented as an abstract for the 2010 American Society of Clinical Oncology (ASCO) Annual Meeting; they have not been published in a peer-reviewed journal yet and until then should be considered preliminary only.

By Ross Bonander

Source: Shanafelt T et al. "Phase II trial of daily, oral green tea extract in patients with asymptomatic, Rai stage 0-II chronic lymphocytic leukemia (CLL). J Clin Oncol 28:7s, 2010 (suppl; abstr 6522)

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