ASH 2013: Adcetris Tested Against B-cell Non-Hodgkin's Lymphomas

Although Adcetris is associated with Hodgkin's and T-cell lymphoma, researchers have been testing the drug for use against non-Hodgkin's lymphomas with some encouraging success.

This ongoing open-label phase II study conducted by researchers at Dana-Farber Cancer Institute and MD Anderson Cancer center, among others, is exploring the activity of the antibody drug conjugate brentuximab vedotin (Adcetris) against relapsed or refractory non-Hodgkin lymphoma (NHL) including diffuse large B cell lymphoma (DLBCL).

A total of 62 patients have been enrolled in the study, including 44 with DLBCL. The majority of patients are heavily pretreated and have refractory disease.

Surprising results

Among the DLBCL patients, 40 percent had an objective response to Adcetris, with a median duration of 36 weeks. Seven patients had complete remissions and 10 had partial responses.

Researchers expressed encouragement over the activity seen against DLBCL, since their hopes weren't all that high.

Adcetris seeks the CD30 protein on the cell surface, which is how it finds the cells it is designed to kill – a protein expressed by maybe one-third of NHL B-cell patients.

Curiously, investigators found that Adcetris seemed to work as well as or better in those patients whose tumor weakly expressed the CD30 protein – this is contrary to all expectation and to preclinical trials.

No explanation for the activity was offered.

Source: ASH

More Articles

More Articles

Mantle cell lymphoma (MCL) is a rare type of B-Cell lymphoma. It presents itself in the mantle zone of lymph nodes...

Large Cell Lymphoma (LCL) is typically an aggressive (fast growing) cancer of either the B cell or T cell type. They are one of the most common...

Indolent Lymphoma, or Indolent Non-Hodgkin’s Lymphomas (NHLs), are slow growing, low-grade cancers (as opposed to ...

A lymphoma prognosis varies greatly depending on the type of lymphoma. There are more than 35 types of lymphoma, including 5 types of...

Lymphomas are classified based on the type of cells involved. Non-Hodgkin’s lymphomas are marked by mutations of...

Hodgkin's Lymphoma (Disease) has a colorful history: It was not the first cancer discovered but it was one of the first in which treatments were...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

Cancer bracelets are undeniably popular, and if purchased through reliable sources such as major charities, they help contribute to the fight...

Hodgkin's Disease—also referred to as Hodgkin's Lymphoma, these are the exact same diseases, just...

Lymphoma is a cancer of the b- and t-cell lymphocytes, part of the immune system. They account for the most frequent head and neck malignancies....

Lymphoma is a cancer of the lymphatic system, causing B-cell or...

Lymphoma is a cancer affecting the white blood cells (lymphocytes) of the body's immune system. The cells begin to grow abnormally and much faster...

As a kind of cancer, lymphoma attacks the lymphocytes and lymph nodes that are part of the immune system. Head and neck lymphoma results when...

Some cancers have clear environmental causes. Oral cancer is strongly tied to the use of chewing tobacco, and lung cancer is well-known to be much...

The Follicular Lymphoma International Prognostic Index, or FLIPI, is a standardized guide to help oncological diagnosticians accurately calculate...