Radiation for Hodgkin's Disease Raises Threat of Breast Cancer in Young Women

Young women with Hodgkin's disease who receive radiation therapy, often the standard treatment, are at increased risk for breast cancer, according to a study supported by the National Cancer Institute (NCI).

To determine the risk of breast cancer, NCI grantees Drs. Steven L. Hancock and Richard T. Hoppe of the Stanford University Medical Center in California, and Dr. Margaret A. Tucker of NCI, reviewed the medical records of nearly 900 patients who were treated for Hodgkins' disease during a three-decade span (1961-1990).

The investigators found that age at irradiation and length of time following therapy proved extremely critical in determining breast cancer risk. The risk increased if patients were younger than age 30 when treatment first began, and increased even more if 15 or more years had passed since radiation therapy was administered in the young women.

As a group, Hodgkin's patients of all ages who received any type of treatment were at a fourfold increased risk for breast cancer, compared with general population rates. Hodgkin's patients treated with radiation at ages 24-29 were at seven times the risk; if younger than 15 when receiving radiotherapy, the risk for breast cancer increased by 136 times.

The findings highlight the significance of vigilant, long-term monitoring of young female patients treated for Hodgkin's disease, which strikes 7,900 Americans each year, including 3,400 females.

Source

Hancock, S.L., M.D., et al., "Breast Cancer After Treatment of Hodgkin's Disease," Journal of the National Cancer Institute, pp. 25-31, Jan. 6, 1993.

lymphoma roundup

More Articles

More Articles

In T cell lymphoma, T lymphocytes, which are an essential part of the body's immune response, become malignant. T cell lymphomas account for about...

Lymphomatoid Papulosis (LyP) is a rare skin disorder that involves cancerous looking skin lesions. It is more than a skin condition; it is the...

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is a relatively rare B-cell subtype of non-Hodgkin'...

T-Cell Lymphoblastic Lymphoma (T-LBL) is a very rare subtype of non-Hodgkin's lymphoma. It tends to develop in...

In general, a diagnosis of T-cell lymphoma denotes a poorer prognosis than a diagnosis of B-cell lymphoma. One of...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

The term NK T cell lymphoma refers to one of two subtypes of lymphoma that affect the NK (Natural Killer)...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...