Gastrointestinal Lymphoma

This entry looks at gastrointestinal lymphoma, better recognized as primary gastric lymphoma, or PGL, one of the subtypes of lymphoma. 'Lymphoma' is an umbrella term that loosely refers to several dozen independent categorical types and subtypes of cancers of the lymphatic system.

What is Gastrointestinal Lymphoma?

The gastrointestinal tract is the most common extranodal site for lymphoma, and PGL accounts for a strong minority of non-Hodgkin's lymphomas (between 7-20%). While PGL is almost always of B-cell origin, gastric NHLs of T-cell origin have been reported. Abdominal pain and nausea are some of the main symptoms of PGL. This disease can present as either indolent or aggressive, but according to studies the difference in survival rates is not statistically significant between the two.

Survival Rates for Gastrointestinal Lymphoma

According to at least one published retrospective study of patients with gastrointestinal lymphoma, the 5-year survival rate, meaning the percentage of people with this cancer who are alive five years from diagnosis, is the following:

Early stage: 80%
Advanced stage: 53.3%

However, this study on gastrointestinal lymphoma determined that the therapeutic intervention that offered the highest 5 year survival rate was one that included surgical resection (removal) of a GI tumor followed by combination chemotherapy, as these patients enjoyed a 90.9% 5 year survival rate. This is considered a change in direction for treatment approaches to gastrointestinal lymphoma, as up until recently while there was controversy over the best treatment, it was generally believed that surgery did not play an important role.

There is a subtype of PGL, a MALT lymphoma caused by the bacteria H. pylori. When patients are diagnosed with this subtype, they generally only require antibiotic treatment.

Sources

Ennibi K et al. Primary gastric lymphoma: a retrospective series of 35 cases Tunis Med. 2008 May;86(5):457-62.

Waisberg J et al. Curative resection plus adjuvant chemotherapy for early stage primary gastric non-Hodgkin's lymphoma: a retrospective study with emphasis on prognostic factors and treatment outcome. Arq Gastroenterol. 2006 Jan-Mar;43(1):30-6.

Kacar, Füruzan; Levi, Edi; Dikicioglu, Emel; Meteoglu, Ibrahim; Et al. "Primary gastric T-cell lymphoma: A case report." Turkish Journal of Cancer. Turkish Association for Cancer Research and Control. 2004.

More Articles

More Articles

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is a relatively rare B-cell subtype of non-Hodgkin'...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

Lymphomatous meningitis [LM], also known as leukemic meningitis, is an extremely serious peripheral cancer that attacks the tissue that covers the...

Since so many chemotherapy agents can affect a patient’s sex drive and fertility, thinking about these issues prior...

Secondary cancers are cancers that develop as a result of chemotherapy and/or...

One of the greatest fears of lymphoma survivors is that they’ll relapse and have to undergo treatment again. This fear is normal but awful to...

Over the years, various classification systems have been used to differentiate lymphoma types including the Rappaport Classification (used until...

If you are new to this website or are looking for guidance to a specific page, here is a list of links to articles that can help you. The "Main...

Often the one who makes the first diagnosis of Hodgkin's Lymphoma / Disease is the person affected. There are some...

Lymphedema is abnormal swelling due to the presence of excess lymphatic fluid within the tissues. This swelling occurs when the...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

Advances in the treatment of Hodgkin's lymphoma have resulted in remarkable survival rates, even for...