Stage 4 Hodgkin's Lymphoma Prognosis

Also known as Hodgkin's disease, Hodgkin's lymphoma (HL) is a cancer of the white blood cells, or lymphocytes. Characterized by swelling in the lymph nodes, HL is most frequently treated with chemotherapy, especially in its later, more advanced stages.

Like many cancers, the spread of Hodgkin's lymphoma can be measured on a scale of four stages, with Stage I being least severe and Stage 4 being most. The following are characteristics of the four stages:

  • Stage 1 Hodgkin's Lymphoma: Stage I involves only a single lymph node, generally in the neck region, or one site outside the lymphatic system. It and Stage II can sometimes be treated with radiation therapy alone.
  • Stage 2 Hodgkin's Lymphoma: Stage II is the involvement of two or more nodes on the same side of the diaphragm.
  • Stage 3 Hodgkin's Lymphoma: Stage III has nodal involvement on both sides of the diaphragm, with possible involvement of the spleen.
  • Stage 4 Hodgkin's Lymphoma: Stage IV, the most serious phase of the disease, finds cancerous involvement of widespread extralymphatic organs (i.e., organs outside the system of lymph nodes).

There Are Options for Stage 4 Hodgkin's Lymphoma

While a diagnosis of Stage IV (Four) Hodgkin's lymphoma is a very serious diagnosis, HL remains one of the most treatable of cancers. It responds well to treatment, whether radiation or chemotherapy. About 60 percent of Stage IV patients will be cured of the disease.

Using the staging of the disease is not, however, always a reliable method of assessing survivability. An international effort in 1998 produced a list of seven factors that are intended to provide a more accurate measure of an individual person's likelihood of responding to treatment.

The scale is based on five-year freedom from progression (FFP), or the percentage of patients whose disease has been successfully halted within five years. Patients with zero factors have an 84 percent FFP. Each of the following factors reduces the 5-year FFP by seven percent:

  • Age greater than 44 years
  • Stage IV
  • Hemoglobin less than 10.5 g/dl
  • Lymphocyte count less than eight percent
  • Patient is male
  • Albumin less than 4.0 g/dl
  • White blood count of 15,000 per microlitre or higher

The reliability of the criteria declines with more than five factors, so for five or more factors, the 5-year FFP is said to be 42 percent.

The Hodgkin's lymphoma Stage IV prognosis is therefore reasonably positive. As one of the "best" cancers to have, Hodgkin's lymphoma is less likely to pose a threat to a patient's life, even in its more advanced stages, than many other diseases.

Photo: Pixabay

Lymphoma Prognosis
w00001
web
chnm3: 
lin

More Articles

More Articles

This entry looks at what is sometimes referred to as mesenteric lymphoma, also referred to as non-Hodgkin's...

In T cell lymphoma, T lymphocytes, which are an essential part of the body's immune response, become malignant. T cell lymphomas account for about...

Lymphoma is a cancer affecting the white blood cells (lymphocytes) of the body's immune system. The cells begin to grow abnormally and much faster...

RICE is an acronym for an anti-cancer treatment that expresses a combination chemotherapeutic regimen. This regimen is written variously as "R+ICE...

B cell lymphoma is not one disease but a few dozen heterogeneous diseases, or individual cancers, that affect the b...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

What causes lymphoma is not well known. DNA mutations may be what causes lymphoma to develop but what triggers these mutations is...

A B cell is a type of lymphocyte that produces antibodies to fight infections. These are the most prevalent lymphocytes in the bloodstream and are...

Canine lymphoma, just like lymphoma in humans, can be separated into stages,...

This article looks at the Non-Hodgkin's Lymphoma survival rate as well as the Non-Hodgkin's Lymphoma mortality rate ....

T-Cell Lymphoblastic Lymphoma (T-LBL) is a very rare subtype of non-Hodgkin's lymphoma. It tends to develop in...

It's not uncommon for patients with some lymphomas to experience itching (clinically known as pruritus). Lymphoma itching symptoms can range from...

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

One of the greatest fears of lymphoma survivors is that they’ll relapse and have to undergo treatment again. This fear is normal but awful to...