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Splenic Marginal Zone Lymphoma
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"Grey's Anatomy"-spleen highlighted in purple
Splenic Marginal Zone Lymphoma (SMZL) is a cancer of the B-cells found in the spleen. The spleen helps the body’s immune system by removing old red blood cells and producing antibodies. This disease is very rare, accounting for less than 1% of all Non-Hodgkin’s Lymphomas, and is rarely found in children. Women are slightly more susceptible than men.
This disease is classified as a marginal zone cancer because the mutation occurs in the marginal zone, or outer compartment, of the affected B-cells.
Diagnosis and Staging
Patients usually have an enlarged spleen, which may cause discomfort or pain. Symptoms can be slow to develop. Patients may also have swollen, painless lymph nodes (though this is very rare) and experience fatigue.
Diagnosis may involve any of the following:
- Biopsy
- Chest X-ray
- PET scan
- CT scan
- Ultrasound
- Bone marrow biopsy
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Staging, as with other lymphomas, depends on the spread of the disease. It is common for patients to have cancer in both the spleen and bone marrow, though progression into the lymph nodes themselves is rare and marks the advanced stages of the disease.
Treatment
There are various treatment options for SMZL:
- Splenectomy
- Surgical removal of the spleen. This can lead to full remission in some patients.
- Immunotherapy
- Rituxan is the most common form of treatment used for SMZL and is very effective. It is occasionally used in combination with chemotherapy.
- Radiation
- Irradiation of the spleen is sometimes necessary.
- Clinical Trials
- Cancer Patients have more options through clinical studies. Follow this link to learn more and find a clinical study opportunity near you.
- Radioimmunotherapy
- Zevalin shows promising results as a treatment for marginal zone lymphomas in clinical trials
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For nearly 30 years, Cancer Treatment Centers of America has been dedicated to finding the right combination of personalized cancer treatments for their patients. Call (877) 399-6937 or click here to learn more about treatment options.
Support Groups
For individuals, friends and families who are looking to connect during life's challenging times. Share personal experiences, evaluate information and get support during times of need, illness, treatment or recovery.
Find a Treatment Facility Near You
Click on a state below to find Lymphoma treatment options that could be right for you.
Select a State Below
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- Alaska
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