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Lymphoma Information Network » Lymphoma Info » Marginal Zone Lymphomas

Marginal Zone Lymphomas

Marginal zone lymphoma, lymph node
from Univ. Tokushima

Marginal zone lymphomas (MZL) are indolent lymphomas that affect the B-cells. The marginal zone is the area in the B-cell in which the mutation occurs in this type of cancer. MZLs represent 2-4% of all NHL cases.

Nodal marginal zone lymphomas involved the lymph nodes directly. Extranodal marginal zone lymphomas involve only organs outside of the lymphatic system, such as the thyroid, GI tract, or skin. These extranodal cancers are also called mucosa-associated lymphatic tissue lymphomas lymphomas, or MALT lymphomas.

Splenic marginal zone lymphomas are considered a class of their own.

Treatment

Treatment varies depending on the type of disease and stage. Radioimmunotherapy treatments such as the Zevalin regimen, though not yet approved for mainstream use, show promising results as MZL therapy. Patients who are looking for more advanced treatment or who have lymphoma that does not respond to standard treatment may want to consider a clinical study. Click here to find clinical trials in your area.

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Featured Treatment: Zevalin®

Zevalin® (Ibritumomab tiuxetan) is a form of radioimmunotherapy (a radiolabeled monoclonal antibody) for treatment of patients with relapsed or refractory, low‑grade or follicular B‑cell non‑Hodgkin's lymphoma (NHL). "Refractory" refers to a disease that does not respond to treatment.

Zevalin is the first radioummunotherapy treatment to be FDA-approved as a first-line therapy for lymphoma. Read more...

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SupportGroups.com aims to build awareness and provide support for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma. If you are a friend or parent of a person that has been diagnosed with Lymphoma, or you have been diagnosed with Lymphoma, you are not alone. Share personal experiences, evaluate information and get support during times of need, illness, treatment or recovery.

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Since the early 1970s, incidence rates for non-Hodgkin’s lymphoma have nearly doubled. Incidence rates for Hodgkin’s disease have declined about 60%. Better means of diagnosis has also increased the number as doctors better understand cancer of lymphocytes verses other diseases.
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