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| Site Navigation | Angioimmunoblastic T-Cell Lymphoma |
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| Angioimmunoblastic lymphoma
(AIL)
is an aggressive T-cell lymphoma
representing about 1-2% of all types of Non-Hodgkin's Lymphoma in the
US. It has in the past been called Angioimmunoblastic
Lymphadenopathy With Dysproteinemia (AILD). Initially was thought to
represent an abnormal reaction of the immune system but it is now known to
be a form of lymphoma. It is now a distinct entity under the newer WHO
classification system.
Presentation |
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| AIL is a type of peripheral T-cell lymphoma that is clinically characterized by high fever, night sweats, weight loss, skin rash, a positive Coomb’s test, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy that sometimes has cutaneous (skin) involvement. | |||
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This malignancy usually occurs in adults. Patients are usually aged 40-90 years (median around 65) and are more often male. As AIL progresses, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia may develop. The skin is involved in approximately 40-50% of patients. Other symptoms can include weight loss, hepatomegaly, polyclonal hyperglobulinemia, and generalized adenopathy (lymph swelling). Treatment Although steroid therapy initially is beneficial in many patients, the disease usually progresses to another form of lymphoma (e.g., to high-grade T-cell immunoblastic lymphoma or Epstein-Barr virus positive diffuse large b-cell lymphoma). Stem Cell transplantation has been selectively used for advanced cases. Further Reading / In-DepthNon-Hodgkin's Lymphomas, Peter M. Mauch (Editor), James O. Armitage (Editor), et al., 2004.
Web Resources:
Information Sources:
Non-Hodgkin's Lymphoma Information Pages: Non-Hodgkin's
Lymphomas The Main Page: This page is a work in progress - if you have more complete information, references, or other information please contact the author. The author is not in the medical field and does not warrant the correctness of the material on this page or the sites linked - please take online information and consult with your own medical team to make informed decisions. Copyright © 1998-2005 Lymphoma Information
Network - All Rights Reserved |
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