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Adult Hodgkin's Lymphoma: Chemotherapy

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By a lymphoma survivor:

Other Hodgkin's / Lymphoma Titles:

Chemotherapy is the use of drugs to kill cancer cells and shrink tumors. Chemotherapy may be taken by pill, or it may be put into the body by infusion into a vein. Chemotherapy is called a systemic treatment because the drugs enter the bloodstream, travel through the body, and can kill cancer cells throughout the body. Chemotherapy Help

Questions for your medical team

Side Effect
Warning Signs

The mainstream chemotherapy regimen is:

Other treatments that may be used, especially for disease that is resistant to other treatments:

Other regimens being used:

A 1997 study in the Annals of Oncology suggest that people who have stage III or stage IV Hodgkin's and only achieve partial remission with chemotherapy can have a high remission success rate with follow-up radiation therapy.
 

 
Bone marrow transplantation
(BMT) and peripheral blood stem cell transplantation (PBSCT) are the use of high doses of chemotherapy with a rescue of the immune system afterwards.  More on the Transplantation Information Page.

Clinical trials are often used for people who are not responsive to conventional treatment or who wish to help researchers test new therapies.

New Treatments - the use of Rituxan in Hodgkin's is in trials now.  Rituxan has previously only been approved for B-Cell Non-Hodgkin's Lymphomas.  The theory explained after the 2003 American Society of Hematology meetings is the Reed-Sternberg cells are surrounded by many normal B lymphocyte cells.  These B cells exchange chemicals with the Reed-Sternberg cells (the cancer cells in Hodgkin's) possibly keeping them alive.  If the B cells are reduced by using Rituxan or another B cell target monoclonal antibody then possibly the Reed-Sternberg cells would be starved to death.  Keep an eye on these studies and others using immunotherapy.

A list of questions you can use to discuss chemotherapy treatment options and warning signs to look for during treatment.

For specific types of treatment see the NCI data sheets listed under the Hodgkin's Resources Page.


In-Depth

Chemotherapy is delivered many different ways depending on the drugs and treatment. Intravenous means delivered by inserting a needle in a vein, orally is by mouth, and via catheter or port is by a tube inserted into the chest via a surgical procedure.  As always consult with your own doctors on the best treatment for you given your specific disease and its presentation.

Reference Books

  • Hodgkin's Disease, Peter M. Mauch (Editor), James O. Armitage (Editor), Volker Diehl (Editor), June 1999.
    • Chapter 22: Principles of Chemotherapy in Hodgkin's Disease
        
  • Living With Lymphoma, Elizabeth Adler, Oct. 2005
    • Chapter 3: Chemotherapy

Drug Information

Catheters

Side Effects

Supportive Care

  • Supportive Care Information from NCI (updated)

    Anxiety Disorder
    Constipation, impaction, and bowel obstruction
    Delirium
    Depression
    Fatigue
    Fever, chills, and sweats
    Hypercalcemia
    Nausea and vomiting
    Pruritus (itching)
    Sleep Disorders

Bone Marrow and Peripheral Blood Cell Information

Nutrition

Clinical Trials


Further Reading on Adult Hodgkin's Disease / Lymphoma:

For Information on Childhood Hodgkin's Lymphoma:

The Main Page - your guide to support and more:


This page is a work in progress - if you have more complete information, references, or other information please contact the author. The author is not in the medical field and does not warrant the correctness of the material on this page or the sites linked - please take online information and consult with your own medical team to make informed decisions.

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Updated November 18, 2005