Chemotherapy - Mustargen

Mechlorethamine molecule

Generic Name: Mechlorethamine

Other Names: Nitrogen Mustard, Mustine

Mustargen is a chemotherapy drug that is administered for the treatment of lung cancer, breast cancer, and lymphomas. It functions as an alkylating agent, meaning it interferes with DNA reproduction and cell replication.

The drug is usually administered for the treatment of Hodgkin’s Lymphoma and Cutaneous T-Cell Lymphoma, a Non-Hodgkin’s Lymphoma. It is commonly used in conjunction with other chemotherapy drugs in the following regimens:

• MOPP (mustargen, oncovin, procarbazine, prednisone)
• Stanford-V (adriamycin, mustargen, bleomycin, vinblastine, oncovin, etoposide, prednisone)

Drug Administration

For the treatment of Hodgkin’s Disease, it is administered via an IV drip. The drug should only be injected into a vein, not an artery, as it can cause irritation. If redness or swelling occurs at the injection site, notify a doctor immediately.

For the treatment of Cutaneous T-Cell Lymphoma, it is applied as a topical cream to the skin to help with skin lesions.

Side Effects

Common side effects include vomiting, low blood counts, mouth sores, hair loss, and infertility. If the drug is used topically, then redness or dryness of the skin can occur.

Less common side effects include loss of appetite, tinnitus (ringing in the ears), taste changes, fever, and diarrhea. In some cases, patients may develop a secondary cancer, such as leukemia.

More Information

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If you or a loved one has been diagnosed with Lymphoma, please call toll-free 1-877-399-5078 for treatment options.

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For more information on Hodgkin's Disease, please see the following pages:

• Adult Hodgkin's Lymphoma: Diagnosis
• Adult Hodgkin's Lymphoma: Treatment
• Adult Hodgkin's Lymphoma: Introduction
• Childhood Hodgkin's Lymphoma: Diagnosis
• Childhood Hodgkin's Lymphoma: Treatment
• Childhood Hodgkin's Lymphoma: Introduction

For more information on Non-Hodgkin Lymphoma, please see the following pages:

• Adult Non-Hodgkin's Lymphoma: Diagnosis
• Adult Non-Hodgkin's Lymphoma: Treatment
• Adult Non-Hodgkin's Lymphoma: Introduction
• Childhood Non-Hodgkin's Lymphoma: Diagnosis
• Childhood Non-Hodgkin's Lymphoma: Treatment
• Childhood Non-Hodgkin's Information Pages