Dacarbazine (common brand names DTIC, DTIC-Dome) is a chemotherapy agent used in the treatment of Hodgkin's Disease. It is more often than not given in conjunction with other chemotherapy agents in a multidrug regimen such as ABVD. An alkylating agent, it functions as a methylating agent after metabolic activation in the liver. Dacarbazine is also used to treat melanoma, a cancer of the skin.
Before taking this medicine: Inform your doctor if you have allergies, are pregnant or plan to have children, are breast feeding, taking other medications including those over the counter, have any other medical problems, have ever been treated with radiation or for cancer.
While taking this medicine: Keep in touch with your doctor regularly. Do not get any vaccinations without checking with your doctor.
Short Term Side Effects: Common: Redness, pain, or swelling at the site of injection, nausea, vomiting. Less Common: black stools, blood in urine or stool, cough, fever/chills, lower back/side pain, painful or difficult urination, pinpoint red spots on skin, sores in mouth and on lips.
Long Term Side Effects: Some hair loss which should return after treatment, transient (shorter term) reduction in liver and kidney function.
Regimens using Dacarbazine:
• ABVD (Hodgkin's Disease - the "D")
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Resources
Manufacturer's Information from Bayer (PDF format, Adobe Acrobat reader / plug-in required)
Information on dacarbazine from Healthtouch (US)
Information sheet from CanCareSA (Australia)
Information on Alkalating Agents including dacarbazine from UNMC (bottom of page)
Manufacturer:
Ben Venue Laboratories, Inc
A division of Boehringer Ingelheim Pharmaceuticals Inc.
300 Northfield Road Bedford, OH 44146 USA
Distributors:
Miles Pharmaceutical, Inc. / Bayer Pharmaceutical
Customer Information: 800-998-9180
Address: 400 Morgan Lane West Haven, CT 06516
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For more information on Hodgkin's Lymphoma, please see the following pages:
Adult Hodgkin's Disease: Chemotherapy
Adult Hodgkin's Lymphoma: Treatment
Adult Hodgkin's Lymphoma: Introduction
Childhood Hodgkin's Disease: Chemotherapy
Childhood Hodgkin's Lymphoma: Treatment
Childhood Hodgkin's Lymphoma: Introduction
