Chemotherapy - Dacarbazine

Brand Names: DTIC-Dome, DTIC, DIC, Imidazole Carboxamide

Dacarbazine is a chemotherapy drug that is administered for the treatment of melanomas, neuroblastoma, and lymphomas. It functions as an alkylating chemotherapy agent, meaning it interferes with DNA reproduction in fast growing cells, thus preventing cell duplication and growth.

This drug is used primarily in the treatment of Hodgkin’s Disease. It is commonly used in conjunction with other chemotherapy drugs in the ABVD treatment regimen (adriamycin, bleomycin, oncovin, dacarbazine).

Drug Administration

Dacarbazine is given intravenously. The injection site should be monitored, as the drug is a known irritant. If any signs of inflammation are observed, a doctor should be alerted immediately.

Side Effects

Common side effects include peripheral neuropathy (numbness or tingling in the hands or feet), flu symptoms, and photosensitivity (sensitivity to light).

There is a small chance of developing leukemia as a secondary cancer, so the doctor should monitor patients after treatment stops.

For more information on Hodgkin's Lymphoma, please see the following pages:

More Articles

More Articles

Secondary cancers are cancers that develop as a result of chemotherapy and/or...

Small lymphocytic lymphoma (SLL), is a type of non-Hodgkin lymphoma characterized by an excess of white blood cells in the...

Lymphoplasmacytic Lymphoma (LPL) is an indolent (slow growing) cancer that affects plasma cells. A plasma cell...

Lymphomas can arise from most any lymphatic tissue (lymph nodes, spleen, thymus, mucosa associated lymphoid...

Treatment for Non-Hodgkin’s Lymphomas (NHL) differs from patient to patient. The regimen used depends on the type of...

Over the years, various classification systems have been used to differentiate lymphoma types including the Rappaport Classification (used until...

Advances in the treatment of Hodgkin's lymphoma have resulted in remarkable survival rates, even for...

The question of what the difference is between leukemia and lymphoma is a commonly asked question. We should start by saying that emerging...

Lymphoma is a cancer of the lymphatic system, causing B-cell or...

As one of two primary categories of lymphatic cancer, Hodgkin's lymphoma (HL) attacks the patient's white...

The diagnosis of a low grade B cell lymphoma is both a specific and a non-specific diagnosis that contains the following components:

What...

Hearing about lymphoma recurrence is about the least-welcome news a patient can hear. But what exactly does it mean?

To begin, lymphoma...

BEAM chemotherapy is an acronym representing a small family of combination chemotherapy regimens that are used chiefly as salvage regimens in the...

This entry looks at a non-Hodgkin's lymphoma called true histiocytic lymphoma (THL), also referred to as diffuse histiocytic lymphoma, and...

The term 'metastatic lymphoma' does not refer to a diagnosis. Unlike many of the subtypes of lymphoma we have...