Chemotherapy - Dacarbazine

Brand Names: DTIC-Dome, DTIC, DIC, Imidazole Carboxamide

Dacarbazine is a chemotherapy drug that is administered for the treatment of melanomas, neuroblastoma, and lymphomas. It functions as an alkylating chemotherapy agent, meaning it interferes with DNA reproduction in fast growing cells, thus preventing cell duplication and growth.

This drug is used primarily in the treatment of Hodgkin’s Disease. It is commonly used in conjunction with other chemotherapy drugs in the ABVD treatment regimen (adriamycin, bleomycin, oncovin, dacarbazine).

Drug Administration

Dacarbazine is given intravenously. The injection site should be monitored, as the drug is a known irritant. If any signs of inflammation are observed, a doctor should be alerted immediately.

Side Effects

Common side effects include peripheral neuropathy (numbness or tingling in the hands or feet), flu symptoms, and photosensitivity (sensitivity to light).

There is a small chance of developing leukemia as a secondary cancer, so the doctor should monitor patients after treatment stops.

For more information on Hodgkin's Lymphoma, please see the following pages:

chemotherapy

More Articles

More Articles

In T cell lymphoma, T lymphocytes, which are an essential part of the body's immune response, become malignant. T cell lymphomas account for about...

Lymphomatoid Papulosis (LyP) is a rare skin disorder that involves cancerous looking skin lesions. It is more than a skin condition; it is the...

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is a relatively rare B-cell subtype of non-Hodgkin'...

T-Cell Lymphoblastic Lymphoma (T-LBL) is a very rare subtype of non-Hodgkin's lymphoma. It tends to develop in...

In general, a diagnosis of T-cell lymphoma denotes a poorer prognosis than a diagnosis of B-cell lymphoma. One of...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

The term NK T cell lymphoma refers to one of two subtypes of lymphoma that affect the NK (Natural Killer)...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...