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Seattle Genetics begins combination trial of SGN-35 plus ABVD

Seattle Genetics and Millennium Pharmaceuticals have announced the initiation of a Phase I multi-center clinical trial of their highly anticipated antibody-drug conjugate brentuximab vedotin in combination with the ABVD chemotherapy regimen, widely regarded as the gold standard in the treatment of Hodgkin's lymphoma.

Brentuximab vedotin (formerly known as SGN-35), which targets the CD30 protein on cancer cells, is currently in a trio of single-agent clinical trials:

- A clinical trial conducted under a Special Protocol Assessment (SPA) with the FDA for relapsed or refractory Hodgkin's lymphoma;
- A Phase II trial for relapsed or refractory systemic anaplastic large cell lymphoma;
- A Phase II retreatment trial for relapsed patients who previously responded to the therapy.

Additionally, a phase III relapse prevention trial is scheduled to be initiated by summer of 2010 for post-transplant Hodgkin's patients.

By Ross Bonander
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Since the early 1970s, incidence rates for non-Hodgkin’s lymphoma have nearly doubled. Improved diagnosis has contributed greatly to the increase as doctors better understand cancer of lymphocytes and can distinguish it from other diseases.
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