Avastin plus R-CHOP trial for DLBCL halted for safety reasons

Submitted by Ross Bonander Fri 06/04/2010

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An independent safety monitoring board has recommended that Roche, makers of Avastin, stop enrolling patients in a phase III trial that had been designed to test the safety and efficacy of adding Avastin to R-CHOP for the treatment of patients with diffuse large B-cell lymphoma (DLBCL).

The recommendation was made after initial data from 720 patients indicated that the benefits did not outweigh the risks.

Avastin remains Roche's biggest selling cancer drug despite this, and despite the fact that the drug failed to provide any benefits in previous trials to patients with gastric and prostate cancers.

Nonetheless, the drug is FDA approved in various combinations for metastatic colorectal cancer, non-small cell lung cancer, metastatic breast cancer, metastatic kidney cancer, and glioblastoma.

By Ross Bonander

Ross, what were the reported

Submitted by loveofmylife on Wed, 06/09/2010 - 19:10.

Ross, what were the reported risks? Do we know?

I'll look it up, but unless

Submitted by Ross Bonander on Tue, 09/14/2010 - 01:17.

I'll look it up, but unless Roche received public funds to run this trial, the data may not be available to the public. Generally the drug companies aren't keen to release negative data like this, so if they don't have to, they probably won't. But if there's public money involved, then the data should be available, if not published anywhere, then through the Freedom of Information Act.

Sadly, Ross is spot on here.

Submitted by Gerald Thompson on Tue, 10/04/2011 - 16:10.

Sadly, Ross is spot on here. Public funds are needed to keep this from being proprietary if it does in fact work out.
Gerald

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