Antibiotics maybe not enough to stop recurrent gastric lymphoma caused by Helicobacter pylori

Research led by Dr. Anne Mueller at Stanford Univ. School of Medicine demonstrates that successful eradication of Helicobacter may not prevent future aggressive gastric lymphoma since resting B cells are left behind. Mueller's paper, "The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of Helicobacter-induced MALT lymphoma," appears in the September issue of The American Journal of Pathology.

Helicobacter pylori, a stomach bacterium, infects more than half of the world's population. It's now widely accepted that, aside from gastritis and ulcers, H. pylori can also cause gastric lymphoma, specifically gastric B cell lymphoma of mucosa-associated lymphoid tissue (MALT). While antibiotic treatment eradicates the bacteria and promotes tumor regression, the effects of reinfection on disease are more severe. News Release

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