Allogeneic Stem Cell Transplant Effective for Refractory Cutaneous Lymphoma

According to a recent article published in the Journal of Clinical Oncology, an allogeneic stem cell transplant appears effective in the treatment of cutaneous T-cell lymphomas that have stopped responding to standard therapies.

Researchers from the City of Hope National Medical Center recently analyzed data from eight patients with cutaneous T-cell lymphomas, Sezary syndrome, and mycoses fungoides. These types of lymphomas affect the skin of patients. The data included patients who had stopped responding to several prior therapies. Four patients underwent an allogeneic stem cell transplant including high doses of therapy, and four underwent non-myeloablative allogeneic stem cell transplants.

All patients achieved a complete disappearance of detectable cancer. Two patients ultimately died from complications associated with treatment. At a follow-up of 56 months, the remaining six patients are alive and cancer-free. Patients treated with the non-myeloablative transplants suffered from fewer side effects. More Info

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