Predicting Follicular NHL Aggressiveness

Scientists at the US National Cancer Institute (NCI) have created a model that predicts the survival of follicular lymphoma patients based on the molecular characteristics of their tumors at diagnosis. The model is based on two sets of genes, called survival-associated signatures, whose activity was found to be associated with good or poor prognosis for patients with the cancer. The scientists' results suggest that immune cells infiltrating follicular lymphoma tumors have an important impact on survival; both signatures came from such immune cells.
The growth rate of follicular lymphoma, the most common non-Hodgkin's lymphoma, varies widely. "In some patients the disease progresses slowly over many years, whereas in others progression is rapid, with the cancer transforming into aggressive lymphoma and leading to early death" explained principle investigator Louis M. Staudt, M.D., Ph.D.

You can read more in the November 19, 2004, New England Journal of Medicine

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