More Clues in the Causes of B-Cell Lymphoma
Researchers at St. Jude Children's Research Hospital have found that the TEL2 gene cooperates with the previously discovered MYC gene in promoting cases of childhood lymphoma. The study's findings help explain the interlocking roles of MYC, TEL2, and p53 in the development of B lymphoma. It was already known that many human B-cell lymphomas over-express the MYC gene, either because the tumor cells acquire additional copies of this gene or because the cells suffer mutations that affect control over the level of MYC expression. Excess MYC expression spurs the cells to proliferate. P53 tells them not to die and there you have it.