Anti-nausea: Kytril / Granisetron

Kytril® (generic name Granisetron) is a drug used to fight nausea (wanting to vomit - the medical term for a drug to prevent nausea is antiemetic). The injectable form was approved by the US FDA for chemotherapy induced nausea in December 1993. It has since been used for radiation therapy induced nausea.

What does Kytril do?

Kytril is a selective blocking agent of the serotonin 5-HT3 receptor. In plain speak serotonin is released by the small intestine when given chemotherapy (and possibly in reaction to other events). This triggers the vomiting reflex. If this mechanism can be blocked with drugs such as Kytril, vomiting can be reduced or eliminated.

Other tidbits

Kytril drug has been hailed by many cancer patients as a miracle in keeping nausea in check. This comes at a price - the drug is expensive. Insurance, if you have it, may cover some of the cost.

Forms of this drug

Kytril comes in injectable (by vein) and oral (by mouth) form. The injectable form is often given in conjunction with chemotherapy. The oral form is suited for doctor prescribed patient use after chemotherapy or radiotherapy.

Dosing

Please refer to your doctor on dosing for this drug given your condition. The medicine should not be given to others or us it for conditions not prescribed by your medical team. Seek medical attention on overdose.

Side Effects

Kytril may cause headache, constipation, weakness, drowsiness, or diarrhea. Don't operate machinery until you know how you react to this drug. You will want to discuss with your doctor the use of this drug if you are pregnant or breastfeeding.

Related Articles

For more information on Hodgkin's Lymphoma, please see the following pages:

More Articles

More Articles

This entry looks at Non Hodgkin's Lymphoma in the lungs, clinically known as pulmonary lymphoma, one of the subtypes of lymphoma. 'Lymphoma' is an...

In order to prevent developing any subtype of lymphoma, it would be helpful to know the causes of lymphoma. Unfortunately, in virtually every case...

BEAM chemotherapy is an acronym representing a small family of combination chemotherapy regimens that are used chiefly as salvage regimens in the...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

The Erythrocyte Sedimentation Rate (ESR - sometimes called sed rate or sedimentation rate) is a nonspecific screening test for various...

Blood counts can be used to identify disease and monitor patient health during cancer treatments. Though these tests cannot diagnose lymphoma on...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

According to a study by Japanese researchers, the SMILE combination chemotherapy protocol is effective against extranodal natural killer/T-cell...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Patients treated with maintenance rituximab had three times longer progression-free survival. This is a summary of an article published in the...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...

Since so many chemotherapy agents can affect a patient’s sex drive and fertility, thinking about these issues prior...