Researchers uncover novel strategy to treat large B-cell lymphomas

Working independently of one another, two groups of researchers have uncovered a possible strategy involving a protease enzyme known as MALT1 to boost the effectiveness of treatment against diffuse large B-cell lymphoma (DLBCL), the most common form of non-Hodgkin's lymphoma.

MALT1 is a protease enzyme; inside a cell it breaks down proteins. Prior research indicates that MALT1 also helps to "activate a signaling pathway that drives the growth of DLBCL cells called the nuclear factor-kappa B (NF-κB) pathway", according to the report in a recent NCI Cancer Bulletin.

Call

When they inhibit MALT1's ability to do its job, researchers have found that they also shut down that signaling pathway, preventing growth and causing the cancerous B-cells to die.

The research teams included one working out of Technical University of Munich, and another out of the National Cancer Institute's Center for Cancer Research and Switzerland's University of Lausanne.

By Ross Bonander
Call

More Articles

More Articles

This entry looks at Non Hodgkin's Lymphoma in the lungs, clinically known as pulmonary lymphoma, one of the subtypes of lymphoma. 'Lymphoma' is an...

In order to prevent developing any subtype of lymphoma, it would be helpful to know the causes of lymphoma. Unfortunately, in virtually every case...

BEAM chemotherapy is an acronym representing a small family of combination chemotherapy regimens that are used chiefly as salvage regimens in the...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

The Erythrocyte Sedimentation Rate (ESR - sometimes called sed rate or sedimentation rate) is a nonspecific screening test for various...

Blood counts can be used to identify disease and monitor patient health during cancer treatments. Though these tests cannot diagnose lymphoma on...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

According to a study by Japanese researchers, the SMILE combination chemotherapy protocol is effective against extranodal natural killer/T-cell...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Patients treated with maintenance rituximab had three times longer progression-free survival. This is a summary of an article published in the...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...

Since so many chemotherapy agents can affect a patient’s sex drive and fertility, thinking about these issues prior...