Transplants no benefit in advanced follicular lymphoma

Results of a systematic review and meta-analysis of randomized control trials ranging from 1947 through 2009 showed researchers that high-dose chemotherapy followed by stem cell transplantation did not improve overall survival in patients with advanced, treatment naive follicular lymphoma compared to chemotherapy alone.

The results were published in the December issue of the Journal of the National Cancer Institute (JNCI), and the research was done by Murtadha Al Khabori of the Division of Medical Oncology and Hematology at the Princess Margaret Hospital in Toronto and his colleagues.

Stem cell transplantations are not common in follicular lymphoma, and to some degree this retrospective study may help bolster current therapies of choice, the watch-and-wait as well as maintenance rituximab.

Source: JNCI

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