What is Marginal Zone Lymphoma?

There are two organs considered to be primary lymphoid organs: the thymus and the bone marrow. Then there are secondary lymphoid organs, and this includes the lymph nodes as well as the largest secondary lymphoid organ, the spleen.

The marginal zone is an area within the spleen that is populated by lymphocytes and macrophages. Blood-born antigens and lymphocytes enter the spleen, and their first stop is in the marginal zone. When lymphocytes in this area become cancerous, it is referred to as a marginal zone lymphoma and will be a B-cell non-Hodgkin's lymphoma.

What are The Types of Marginal Zone Lymphoma?

There are three generally recognized subtypes of marginal zone lymphoma. They are:

There are also some types within these subtypes, such as pulmonary marginal zone lymphoma (BALT) and primary cutaneous marginal zone lymphoma, affecting the skin.

These are fairly rare subtypes of lymphoma, accounting for about 2 to 4 percent of all NHLs, or no more than around 2,200 or so cases annually in the United States.

What is The Prognosis of Marginal Zone Lymphoma?

The five year overall survival rates for the three subtypes of marginal zone lymphoma are as follows:

  • Splenic marginal zone lymphoma (SMZL): 93%
  • Nodal marginal zone lymphoma: 89%
  • Extranodal marginal zone lymphoma (also known as MALT lymphoma): 87%

These rates are affected by a patient's age and gender, as well as their overall health, and whether or not they are symptomatic, among other factors.

Sources

Kindt, Thomas J et al. Immunology: Sixth Edition. WH Freeman and Company. New York.

Mazloom A et al. Marginal zone lymphomas: factors that affect the final outcome.

Photo: Pexels

More Articles

More Articles

In T cell lymphoma, T lymphocytes, which are an essential part of the body's immune response, become malignant. T cell lymphomas account for about...

Lymphomatoid Papulosis (LyP) is a rare skin disorder that involves cancerous looking skin lesions. It is more than a skin condition; it is the...

In non-Hodgkin's lymphoma, you have your B-cell lymphomas and you have your T-cell lymphomas.

Why B...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is a relatively rare B-cell subtype of non-Hodgkin'...

T-Cell Lymphoblastic Lymphoma (T-LBL) is a very rare subtype of non-Hodgkin's lymphoma. It tends to develop in...

In general, a diagnosis of T-cell lymphoma denotes a poorer prognosis than a diagnosis of B-cell lymphoma. One of...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

The term NK T cell lymphoma refers to one of two subtypes of lymphoma that affect the NK (Natural Killer)...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...