Intraocular Lymphoma

This entry looks at intraocular lymphoma, known as primary intraocular lymphoma (PIOL), one of the subtypes of lymphoma. 'Lymphoma' is an umbrella term that loosely refers to several dozen independent categorical types and subtypes of cancers of the lymphatic system.

When a primary lymphoma is found in the eye (an 'ocular lymphoma), it can be categorized as either:

-- Intraocular lymphoma, meaning it is developing within the eye

or

-- Orbital adnexal lymphoma, meaning it is developing in the areas around the eye

Intraocular lymphoma can be of B-cell or T-cell origin. It can also be a secondary site, and therefore be considered a subtype of primary central nervous system lymphoma (PCNSL), and this is in fact the biggest concern with intraocular lymphoma—that it is found to have spread from the central nervous system (CNS). Prognosis in these cases is very poor. Typically, if a diagnosis of intraocular lymphoma is made, then it is followed by a complete neurological work-up to see if there is any CNS involvement or not.

Symptoms of Intraocular Lymphoma

Symptoms of PIOL include:

-- Decreased vision
-- Vitreous floaters (you know, those little fibers and shapes we kind of see in the corners of our eyes but can never actually look at. They're common in us all, but if there is a big increase, then it's a concern. Vitreous is a substance that makes up most of the eye; as it shrinks, floaters form).
-- Uveitis (swelling of the middle layer of the eye, the uvea)

Treatment for Intraocular Lymphoma

If the disease is localized—meaning it has not spread to distant sites in the body, then chemotherapy loses its appeal as an effective treatment because chemotherapy drugs go everywhere in the body, and if the disease is only in the eye, the odds of getting good distribution of the chemo in that area are not good. Rather, the preferred treatment is known as external beam radiation, and the effective doses are considered to be on the low end, which is good.

Sometimes chemotherapy is used after radiation, as a means of 'mopping up' any remaining cancer cells missed by the radiation.

The 5 year overall survival rate for intraocular lymphoma is said to be around 60%.

Sources

MedScape, Ocular lymphoma

Karma A et al. Primary intraocular lymphoma: improving the diagnostic procedure. Opthamology 2007 Jul;114(7):1372-7.

Eye Cancer Network, Intraocular lymphoma

National Eye Institute, Facts about floaters

More Articles

More Articles

Mantle cell lymphoma (MCL) is a rare type of B-Cell lymphoma. It presents itself in the mantle zone of lymph nodes...

Large Cell Lymphoma (LCL) is typically an aggressive (fast growing) cancer of either the B cell or T cell type. They are one of the most common...

Indolent Lymphoma, or Indolent Non-Hodgkin’s Lymphomas (NHLs), are slow growing, low-grade cancers (as opposed to ...

A lymphoma prognosis varies greatly depending on the type of lymphoma. There are more than 35 types of lymphoma, including 5 types of...

Lymphomas are classified based on the type of cells involved. Non-Hodgkin’s lymphomas are marked by mutations of...

Hodgkin's Lymphoma (Disease) has a colorful history: It was not the first cancer discovered but it was one of the first in which treatments were...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

Cancer bracelets are undeniably popular, and if purchased through reliable sources such as major charities, they help contribute to the fight...

Hodgkin's Disease—also referred to as Hodgkin's Lymphoma, these are the exact same diseases, just...

Lymphoma is a cancer of the b- and t-cell lymphocytes, part of the immune system. They account for the most frequent head and neck malignancies....

Lymphoma is a cancer of the lymphatic system, causing B-cell or...

Lymphoma is a cancer affecting the white blood cells (lymphocytes) of the body's immune system. The cells begin to grow abnormally and much faster...

As a kind of cancer, lymphoma attacks the lymphocytes and lymph nodes that are part of the immune system. Head and neck lymphoma results when...

Some cancers have clear environmental causes. Oral cancer is strongly tied to the use of chewing tobacco, and lung cancer is well-known to be much...

The Follicular Lymphoma International Prognostic Index, or FLIPI, is a standardized guide to help oncological diagnosticians accurately calculate...