The Pathophysiology of Lymphoma: Signs and Symptoms That Are Identified

The pathophysiology of lymphoma refers to the process or processes going on inside the body that are sometimes reflected in the signs and symptoms that are identified as being indicative of lymphoma.

For example, swollen, painless lymph nodes are a symptom of lymphoma. Pathophysiology of lymphoma with this symptoms is that it becomes this way when cancerous lymphocytes do not die, as they are supposed to, but rather proliferate and collect at the lymph nodes.

Lymphoma Treatment Center

Insurance Accepted.
Innovative Lymphoma Treatments.
Call 415-343-6162 Today

In cases with 'bulky' disease or tumor masses, as the tumor grows in size it begins to cause problems with the surrounding tissues and organs, causing symptoms that can be indicative of lymphoma.

The Molecular Pathophysiology of Lymphoma

This subject is too specific and too technical for this entry, but in brief what it refers to is the process, at the molecular level, that is believed to result in a lymphocyte becoming cancerous. For instance, in follicular lymphoma, it is very common to find that a specific gene, known as BCL-2, has undergone chromosomal rearrangement—in other words, a structural change has occurred to that gene and is likely the reason it turned cancerous. As it develops, the pathophysiology of lymphoma often includes mutations of certain proteins that encode certain genes, such as p53 and p16. Since the gene encoded by p53 is a tumor suppressor gene, a mutation in p53 could mean that the ability of that gene to suppress tumor development is compromised.

Photo: Pexels

Lymphoma Treatment Center

Insurance Accepted.
Innovative Lymphoma Treatments.
Call 415-343-6162 Today

More Articles

More Articles

This entry looks at Non Hodgkin's Lymphoma in the lungs, clinically known as pulmonary lymphoma, one of the subtypes of lymphoma. 'Lymphoma' is an...

In order to prevent developing any subtype of lymphoma, it would be helpful to know the causes of lymphoma. Unfortunately, in virtually every case...

BEAM chemotherapy is an acronym representing a small family of combination chemotherapy regimens that are used chiefly as salvage regimens in the...

There are two types of cancer: benign and malignant. Benign cancers are the kind that don't spread and don't threaten one's life. Malignant...

The Erythrocyte Sedimentation Rate (ESR - sometimes called sed rate or sedimentation rate) is a nonspecific screening test for various...

Blood counts can be used to identify disease and monitor patient health during cancer treatments. Though these tests cannot diagnose lymphoma on...

MALT lymphoma is a rare B-cell non-Hodgkin's lymphoma that typically runs an indolent or slow-growing clinical...

Mantle cell lymphoma (MCL) is just one of 50-60 known B-cell subtypes of...

After some of the dust has settled, the thoughts of many new lymphoma patients turn to diet and nutrition. They want to know if, in the past,...

According to a study by Japanese researchers, the SMILE combination chemotherapy protocol is effective against extranodal natural killer/T-cell...

In a perfect world, every case of cancer would respond to, and be cured by first-line therapy. Unfortunately, it is not often the case. This is...

Patients treated with maintenance rituximab had three times longer progression-free survival. This is a summary of an article published in the...

Prednisone is a glucocorticosteroid (a steroid) used in the treatment of many types of cancers. It functions as an anti-inflammatory medicine that...

In 1964, researchers at the National Cancer Institute developed the first combination chemotherapy that cured a...

Since so many chemotherapy agents can affect a patient’s sex drive and fertility, thinking about these issues prior...