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What drug can effecively be substituted for bleomycinin Hodgkin's chemotherapy/

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Submitted by Ross on Sat, 11/07/2009 - 23:19.

Bleomycin falls into the anti-tumor antibiotic class- when it gets into the body it causes strands within the DNA of a cell to break, preventing it from dividing and leading to cell death. It does this to cancer cells and healthy cells. In a combination chemo regimen like ABVD, each drug attacks a cell's ability to divide in different ways; it's like bringing a knife, a stun gun, a baseball bat and some brass knuckles to a fight, but while that analogy probably lends itself to imagining another drug like bleomycin being introduced, it's not that easy. More likely a patient who's prone to pulmonary toxicity would be closely monitored on bleomycin, since that's a major side effect.

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