Mantle Cell Lymphoma treatment options

My husband (59) has been diagnoses with Mantle Cell lymphoma and he has been given the following 3 treatment options:
1) HyperCVAD - which from what I have read and been told is a very aggressive treatment with alot of side effects.
2) CHOP-R / BR - All I can find out about this is on CHOP-R
3)clinical trial - Bortezomib (VELCADE), Cladribine and Rituximab (VCR)
I am wondering what would be the better treatment plan for him.
His bone marrow is negative for lymphoma.
Thank you.
Robin

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