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My mother is 74 yrs old and diagnosed with Stage IV CD10+ LrgB cell lymphoma located in her L4 and L5 vertebrae. Starting R-CHOP chemo this week. Does anyone have some insight on what our expectations should be for the coming weeks/months?

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A lot of what to expect
A lot of what to expect depends on the kind of health she's in before she starts chemo, as well as her emotional state during chemo. R-CHOP is a relatively effective chemo regimen, but for people of your mother's age, things can go either way. You might want to post this over at the NHL page at supportgroups.com, since many people there have undergone the R-CHOP regimen and can give you plenty of valued insight. Supportgroups.com is the sister site for this one and part of a wider health network.
Ross