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does anyone know if the treatment is the same for stage 2 or stage 4 NHL... AND IF THEIR BOTH TREATABLE AND CURABLE?

Eyesbrnforever (great sign-in name by the way):

To answer your question accurately requires a bit more information, since NHL can mean a number of different cancers that require different treatment modalities.

The short answer to your question is no—stage II and stage IV will be treated differently. But the other answer is yes--they tend to be highly treatable.

Common types of NHL

The most common types of non-hodgkin's lymphoma are as follows:

Indolent Lymphomas
Follicular lymphoma
Small lymphocytic lymphoma
Marginal zone lymphoma
Extranodal marginal zone lymphoma
Lymphoplasmacytoid lymphoma

Moderately Aggressive Lymphomas
Mantle cell lymphoma
Diffuse large B-cell lymphoma (DLBCL)
Peripheral T-cell lymphoma
Anaplastic large cell lymphoma

Highly Aggressive Lymphomas
Lymphoblastic lymphoma
Burkitt's lymphoma

Staging

In NHL, Stage II means:
"Two or more groups of nodes are affected, but the lymphoma is only on one side of the diaphragm. The diaphragm is the sheet of muscle under the lungs that helps us to breathe. The part of the body above the diaphragm is the upper half, and below the diaphragm is the lower half of the body."

Stage IV means:
"The lymphoma has spread beyond the lymph nodes, for example to other organs such as the bone marrow, liver or lungs."

Because the highly aggressive lymphomas are so rare, I'll leave them out of this response to you.

Staging and treatment

Indolent Lymphomas: Stages I and II
Radiation therapy is considered the standard treatment for indolent lymphomas in stages I and II. Five year survival for these stages is considered to be around 90%.

Indolent Lymphomas: Stage III and IV
This is no standard treatment at these stages. Plenty of disagreement among experts. Some patients (generally those without symptoms) are not treated at all, but merely observed very closely.

Other treatment options include:
Chemotherapy: Common combination regimens such as CHOP, CVP, FND, and CF
Chemotherapy combination regimens plus immunotherapy in the form of adding Rituxan (rituxumab) to the regimen (i.e. R-CHOP).

Five year survival for these stages is considered to be around 80%.

Moderately Aggressive Lymphomas: Stages I and II
The standard treatment here is the chemotherapy regimen R-CHOP.
Some physicians may add radiation therapy to the chemotherapy regimen.

This features a five-year survival rate of 70-90%.

Moderately Aggressive Lymphomas: Stages III and IV
A number of different chemo combination regimens have proven effective, but since CHOP is considered less toxic than others, many consider it the treatment of choice.

For Diffuse large B-cell lymphoma (DLBCL), many now add Rituxan (rituxumab) to the CHOP therapy, since R-CHOP has proven very effective in treating DLBCL.

T-cell lymphomas have not responded well to these chemo regimens. Different regimens have been tried, along with bone marrow or stem cell transplants.

Five year survival rate is broad, between 20-90%, depending on a variety of factors.

I hope this helps.
Ross

Sources:

--Everyone's Guide to Cancer Therapy, revised 5th edition. Ed. Andrew Ko M.D. et al. Andrews McMeel Publishing, Kansas City. 2008.
--Cancerbackup.org.uk: NHL staging
--National Cancer Institute: Non-Hodgkin lymphomas

all i know is that my aunt got a positive bone marrow..and has stage 4 NHL..and that its low grade whatever that means..not sure what type of NHL it is..but thanks for the info


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Since the early 1970s, incidence rates for non-Hodgkin’s lymphoma have nearly doubled. Improved diagnosis has contributed greatly to the increase as doctors better understand cancer of lymphocytes and can distinguish it from other diseases.

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