Maintenance regimen may be effective against multiple myeloma

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According to a small study by Chinese researchers, patients with Multiple Myeloma may benefit from a salvage therapy involving continuous, low-dose treatment with two very familiar chemotherapeutic drugs: cyclophosphamide (Cytoxan) and prednisone.

BLOOD CANCER SUBTYPE(S) IN QUESTION

Multiple Myeloma

COHORT

Patients: 27
Prior treatments: Patients had received between 1 and 4 previous chemotherapy regimens

RESEARCH FINDINGS

In this study, researchers wanted to evaluate the efficacy and tolerability of cyclophosphamide (50mg) and prednisone (15mg) given orally every day. Researchers followed up every two months for a median 11 months.

Results after three months:
Overall response rate: 66.7% (18 patients)
Complete response rate: 7.4% (2 patients)

No response was seen in 25.9% (7 patients) while 7.4% (2 patients) saw their disease get worse.

PUBLICATION & SOURCES

This study was published in the journal Clinical Lymphoma, Myeloma & Leukemia.

By Ross Bonander

Source: Clinical Lymphoma, Myeloma & Leukemia

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